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Investigating a hyper-endemic focus of Taenia solium in northern Lao PDR

机译：调查老挝北部泰国索尔焦利率的超人物重点

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Background The Taenia solium cysticercosis-taeniasis complex is a Neglected Tropical Disease of significant public health importance in many impoverished communities worldwide. The parasite is suspected to be endemic in Lao PDR as a result of widespread risk factors including open human defecation, free ranging pigs and weak systems for meat inspection and carcass condemnation. Reported prevalences of human taeniasis throughout the country have ranged from 0-14%, although few of these have definitively diagnosed T. solium, grossly indistinguishable from Taenia saginata (beef tapeworm) and Taenia asiatica. This short communication details the suspicion of a hyper endemic “hotspot” of T. solium in a remote Tai Dam village in northern Lao PDR. Findings Initial antibody serosurveillance of four provinces in Lao PDR in 2011 indicated human taeniasis and cysticercosis prevalences of 46.7% and 66.7% respectively, in the village of Om Phalong in the north of the country. Subsequent copro-antigen ELISA on 92 human faecal samples from this same village, representing a total 27.9% of the target community, indicated a taeniasis prevalence of 26.1% (95% CI?=?18.2-35.9). Subsequent PCR and sequencing of samples (n?=?5) all identified as T. solium; the other human tapeworms T. saginata and T. asiatica were not detected in any of the samples genotyped. Conclusion This is potentially one of the highest documented prevalences of T. solium taeniasis to date in Lao PDR, if not the Southeast Asia region. This result raises suspicion that other “hotspots” of T. solium hyper endemicity may exist in the region, particularly in communities where the consumption of raw pork is commonplace as a result of cultural practices.
机译：背景技术Taenia源性囊霉菌病 - Taeniaisis复合体是忽视的热带疾病，在许多贫困社区在全世界的许多贫困社区中的重视。由于广泛的危险因素，包括开放的人体排便，自由测距和肉类检查和胴体谴责，因此怀疑寄生虫是在老挝人民PDR中的流行因素。据报道，整个国家的人类巨大症患病率为0-14％，虽然这些含量绝对诊断出源于T.源性，从Taenia Saginata（牛皮绦虫）和Taenia Asiatica非常难以区分。这种短暂的沟通细则详细说明了在老挝北部的偏远Tai Dam Village中的T. Solium的Hypery of Solium的怀疑。研究结果初始抗体在Lao PDR的四个省份在2011年的四个省份表明，在该国北部的Om Phalong村分别表明人类巨大病毒和囊尾病患率分别为46.7％和66.7％。随后的己二烯ELISA来自同一村的92个人粪便样本，总计27.9％的目标群落，表明Taeniasis患病率为26.1％（95％CI？=？18.2-35.9）。随后的PCR和样品测序（N？=β5）全部鉴定为T.棒;在任何基因分型的样本中未检测到其他人绦虫T.Saginata和T.Saginata和T.Asiatica。结论这可能是在老挝人民共和国迄今为止迄今为止的最高记录的T.TaiSitiesis的普遍存在之一，如果不是东南亚地区。这一结果引发了怀疑，该地区可能存在于粘棒超流性的其他“热点”，特别是在植物的消耗是文化实践的结果中。

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