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首页> 外文期刊>Pharmaceutics >Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation
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Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation

机译：CYP3A5遗传多态性频率和特咯患者药代动力学在儿科肝移植中

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The evidence available in the pediatric population is limited for making clinical decisions regarding the optimization of tacrolimus (TAC) in pharmacotherapy. The objective of this study was to estimate the frequency of CYP3A5 genetic polymorphisms and their relationship with tacrolimus requirements in the pediatric population. This was a longitudinal cohort study with a two-year follow-up of 77 patients under 18 years old who underwent a liver transplant during the period 2009–2012 at the J.P. Garrahan Pediatric Hospital. Tacrolimus levels from day five up to two years after the transplant were obtained from hospital records of routine therapeutic drug monitoring. The genotyping of CYP3A5 (CYP3A5*1/*3 or *3/*3) was performed in liver biopsies from both the donor and the recipient. The frequency of CYP3A5*1 expression for recipients was 37.1% and 32.2% for donors. Patients who received an expresser organ showed lower Co/dose, especially following 90 days after the surgery. The role of each polymorphism is different according to the number of days after the transplant, and it must be taken into account to optimize the benefits of TAC therapy during the post-transplant induction and maintenance phases.
机译：儿科人口可获得的证据是有限的，用于制定有关药物治疗中的Tacrolimus（TAC）的临床决定。本研究的目的是估计CYP3A5遗传多态性的频率及其与儿科人群中的巨杆菌需求的关系。这是一个纵向队列研究，在2009 - 2012年在J.P.Garrahan儿科医院的2009 - 2012年期间接受了肝脏移植的77名患者，这是一个纵向队列的研究。从医院常规治疗药物监测的医院记录获得了移植后第五天的巨杆菌水平。 CYP3A5的基因分型（CYP3A5 * 1 / * 3或* 3 / * 3）在来自供体和受体的肝脏活组织检查中进行。对于供助剂的接受者的CYP3A5 * 1表达的频率为37.1％和32.2％。接受患者器官的患者显示出较低的CO /剂量，特别是在手术后90天后。根据移植后的天数，每种多态性的作用是不同的，并且必须考虑到在移植后诱导和维持阶段期间优化TAC治疗的益处。

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