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首页> 外文期刊>Pharmacology Research & Perspectives >Polypharmacy, potentially serious clinically relevant drug‐drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life
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Polypharmacy, potentially serious clinically relevant drug‐drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life

机译：多酚，可能是严重的临床相关药物 - 药物相互作用，患有2型糖尿病的老年人药物及其对生活质量的影响

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The aim of the study is to investigate the patterns of polypharmacy, clinical-relevant drug-drug interactions (DDIs), and potentially inappropriate medicines (PIMs), and whether polypharmacy, potential serious clinically-relevant DDIs, or PIMs can be associated with low quality of life (QoL) index scores of older adults with type 2 diabetes (T2D). A cross-sectional study was conducted using data of 670 elderly T2D sub-cohort from a nationwide pharmacy-based intensive monitoring study of inception cohort of T2D in Portugal. 72.09% were found on polypharmacy (≥5 medicines). Participants on polypharmacy were mostly females (P?=?.0115); more obese (P?=?.0131); have more comorbid conditions (P??.0001); more diabetes complications (P??.0001); and use more of glucose lowering drugs (P?=?.0326); insulin (P??.0001); chronic medicines (P??.0001); and have higher diabetes duration (P?=?.0088) than those without polypharmacy. 10.59% of the participants were found to have potential serious clinically relevant DDIs. The most frequent drug-combinations were angiotensin-converting enzyme (ACE) inhibitors with angiotensin-receptor blockers (ARBs), aspirin with Selective serotonin reuptake inhibitors (SSRIs), and clopidogrel with calcium channel blockers. PIMs are found in 36.11% of the participants. The most common PIMs were benzodiazepines, long-acting sulfonylureas, and iron overdose. The adjusted multivariate models show that Polypharmacy, PIMs, and potential serious clinically relevant DDIs were associated with lower QoL index scores (OR 1.80 95% CI 1.15-2.82), (OR 1.57 95% CI 1.07-2.28), and (OR 1.34 95% CI 0.73-2.48) respectively. The study shows that polypharmacy, potential serious clinical-relevant DDIs, and PIMs may correlate with risk of reduced health related QoL outcome of older adults with T2D.? 2020 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.
机译：该研究的目的是探讨多酚省，临床相关药物 - 药物相互作用（DDIS）的模式，以及可能不合适的药物（PIM），以及复数，潜在的严重临床相关的DDIS，或PIMS可以与低相关生活质量（QOL）指数等级的旧成年人与2型糖尿病（T2D）。使用来自葡萄牙葡萄牙2007年的基于全国性的药房的强化监测研究，使用670名老年人T2D子群组进行了横截面研究。 72.09％关于多酚省（≥5药）。 PolyPharmacy的参与者大多是女性（P？= 0115）;更多肥胖（p？= 0131）;有更多的合并条件（p？<0001）;更多糖尿病并发症（p？<0001）;并使用更多的葡萄糖降低药物（p？= 0326）;胰岛素（p？<0001）;慢性药物（P？<0001）;并且具有较高的糖尿病持续时间（P？= 0088），而不是没有多药物的那些。 10.59％的参与者被发现有潜在的严重临床相关的DDI。最常见的药物组合是血管紧张素转换酶（ACE）抑制剂，血管紧张素受体阻滞剂（ARB），具有选择性羟色胺再摄取抑制剂（SSRIS）的阿司匹林和钙通道阻滞剂的氯吡格林。 PIMS在36.11％的参与者中找到。最常见的PIM是苯二氮卓，长效磺脲类和铁过量。调整后的多变量模型表明，复数，PIM和潜在的严重临床相关的DDIS与低QOL指数评分（或1.80 95％CI 1.15-2.82）相关，（或1.57 95％CI 1.07-28），和（或1.34 95 ％CI 0.73-2.48）分别为0.73-2.48）。该研究表明，复数，潜在的严重临床相关的DDI，以及PIM可能与具有T2D的老年人健康相关QoL结果的风险相关。 2020作者。 John Wiley＆Sons Ltd，英国药理学会和美国药理学学会和实验治疗学士发表的药理学研究与观点。

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