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首页> 外文期刊>Physical Review X >Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport
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Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport

机译：可以导致细胞内运输中玻璃动态的循环状态

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Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations of its dynamics exhibit statistics comparable to those observed experimentally. Analysis of the model trajectories, as well as experimental particle tracking data, reveals a state in which motors cycle unproductively at junctions of three or more filaments. We formulate a master equation for these junction dynamics and show that the time required to escape from this vortexlike state can account for the power-law dwell times. We identify trends in the dynamics with the motor valency for further experimental validation. We demonstrate that these trends exist in individual trajectories of myosin II on an actin network. We discuss how cells could regulate intracellular transport and, in turn, biological function by controlling their cytoskeletal network structures locally.
机译：在活细胞中的分子马达观察到电力法停留时间，但这些陷阱状态的起源是不知道的。我们介绍了一种最小的电动机模式，在长丝的二维网络上移动，其动态的模拟表现出与实验观察的那些相当的统计数据。分析模型轨迹以及实验粒子跟踪数据，揭示了一种状态，其中电机在三个或更多个长丝的结时未生产线性地循环。我们制定了这些结动力学的主方程，并表明逃离此涡旋州所需的时间可以考虑电力法停留时间。我们确定了电动机的动态趋势，以进一步进行实验验证。我们证明这些趋势存在于肌动蛋白网络上的肌球蛋白II的个体轨迹。我们讨论细胞如何调节细胞内运输，然后通过在本地控制其细胞骨骼网络结构来调节细胞内运输。

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