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首页> 外文期刊>PLoS Computational Biology >Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices
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Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices

机译：来自小鼠胰腺组织切片的兰氏汉族胰岛胰岛的功能连接

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摘要

We propose a network representation of electrically coupled beta cells in islets of Langerhans. Beta cells are functionally connected on the basis of correlations between calcium dynamics of individual cells, obtained by means of confocal laser-scanning calcium imaging in islets from acute mouse pancreas tissue slices. Obtained functional networks are analyzed in the light of known structural and physiological properties of islets. Focusing on the temporal evolution of the network under stimulation with glucose, we show that the dynamics are more correlated under stimulation than under non-stimulated conditions and that the highest overall correlation, largely independent of Euclidean distances between cells, is observed in the activation and deactivation phases when cells are driven by the external stimulus. Moreover, we find that the range of interactions in networks during activity shows a clear dependence on the Euclidean distance, lending support to previous observations that beta cells are synchronized via calcium waves spreading throughout islets. Most interestingly, the functional connectivity patterns between beta cells exhibit small-world properties, suggesting that beta cells do not form a homogeneous geometric network but are connected in a functionally more efficient way. Presented results provide support for the existing knowledge of beta cell physiology from a network perspective and shed important new light on the functional organization of beta cell syncitia whose structural topology is probably not as trivial as believed so far.
机译：我们提出了在朗格汉兰胰岛中的电耦合β细胞的网络表示。 β细胞在功能上基于各个细胞钙动力学之间的相关性，通过急性小鼠胰腺组织切片的胰岛中的共聚焦激光扫描钙成像获得。根据胰岛的已知结构和生理性质分析获得的功能网络。专注于葡萄糖刺激下网络的时间演变，我们表明，在激活的情况下，观察到动态在刺激下比在非刺激条件下更加相关，并且在激活中观察到细胞之间的欧氏距离的总体相关性最高。当细胞由外部刺激驱动时失活阶段。此外，我们发现活动期间网络中的相互作用范围显示出对欧几里德距离的明显依赖性，借助于先前观察结果，β细胞通过钙的波在整个胰岛蔓延的钙电池同步。最有趣的是，β细胞之间的功能连接模式表现出小世界性质，表明β细胞不形成均匀的几何网络，而是以功能更有效的方式连接。呈现的结果提供了对从网络角度来看β细胞生理学的现有知识，并在迄今为止的结构拓扑结构拓扑结构的功能组织上阐明了重要的新光照，这是迄今为止所相信的那样微不足道。

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