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首页> 外文期刊>PLoS Genetics >Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons
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Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons

机译：辛辣醇素神经元依赖性侵略需要从双透射神经元的DVGlut

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Neuromodulators such as monoamines are often expressed in neurons that also release at least one fast-acting neurotransmitter. The release of a combination of transmitters provides both “classical” and “modulatory” signals that could produce diverse and/or complementary effects in associated circuits. Here, we establish that the majority of Drosophila octopamine (OA) neurons are also glutamatergic and identify the individual contributions of each neurotransmitter on sex-specific behaviors. Males without OA display low levels of aggression and high levels of inter-male courtship. Males deficient for dVGLUT solely in OA-glutamate neurons (OGNs) also exhibit a reduction in aggression, but without a concurrent increase in inter-male courtship. Within OGNs, a portion of VMAT and dVGLUT puncta differ in localization suggesting spatial differences in OA signaling. Our findings establish a previously undetermined role for dVGLUT in OA neurons and suggests that glutamate uncouples aggression from OA-dependent courtship-related behavior. These results indicate that dual neurotransmission can increase the efficacy of individual neurotransmitters while maintaining unique functions within a multi-functional social behavior neuronal network.
机译：诸如单胺的神经调节剂通常在神经元中表达，该神经元也释放至少一个快速作用的神经递质。发射机组合的释放提供了可以在相关电路中产生多样化和/或互补效果的“经典”和“调制”信号。在这里，我们建立了大多数果蝇八曲（OA）神经元也是谷氨酰胺，并确定每个神经递质对性别特定行为的个体贡献。没有OA的男性显示出低水平的攻击和高水平的男性求爱。单独在OA-谷氨酸神经元（OGNS）中缺乏DVGlut的男性也表现出侵略性的减少，但没有同时增加男性癌症。在OGNS中，VMAT和DVGlut Puncta的一部分在本地化方面不同，表明OA信令中的空间差异。我们的研究结果在OA神经元中建立了以前未确定的DVGlut作用，并表明谷氨酸谷氨酸的侵略来自OA依赖性求婚相关行为。这些结果表明，双神经递质可以增加个体神经递质的疗效，同时在多功能社会行为神经网络网络中保持独特的功能。

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