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Loss of ferritin in developing wing cells: Apoptosis and ferroptosis coincide

机译：开发翼细胞中铁蛋白的丧失：细胞凋亡和脱盐症一致

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Simone Mumbauer and colleagues have studied ferritin’s role in the context of Hippo signaling within Drosophila melanogaster wing primordial cells [1]. Their findings suggest that H and L ferritin subunits may have noninterdependent functions. When subunit H is lost, increased levels of reactive oxygen species and cell death by apoptosis are observed, as well as mitochon- drial hallmarks, which may be defined as ferroptosis [2]. Loss of Hippo signaling in this genetic background rescued cell death, despite the reactive oxygen species, which persisted. Does loss of Hippo signaling in a developmental context protect from ferroptosis? In mesenchymal and renal carcinoma cells, however, loss of Hippo signaling correlates with susceptibility to ferrop- tosis [3, 4]. These apparently contrasting findings call for an explanation.
机译：Simone Mumbauer及其同事们在果蝇在果蝇Melanogaster翼原基细胞中的河马信号传导中研究了Ferritin的作用[1]。他们的研究结果表明H和L铁蛋白亚基可能具有非互相依存功能。当亚单位H丢失时，观察到通过细胞凋亡的反应性氧物质和细胞死亡水平增加，以及线粒体标志，其可以定义为脱盐剂[2]。尽管活性氧物种持续存在，但河马信号在该遗传背景中失去了河马信号传导。在发育中的情境保护中丧生河马信号丧失吗？然而，在间充质和肾癌细胞中，河马信号传导的丧失与铁铁膜的易感性相关[3,4]。这些显然对比的调查结果来呼吁解释。

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