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首页> 外文期刊>Ukrainian Biochemical Journal >Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations
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Proline dehydrogenase (PRODH) gene polymorphisms and the risk of schizophrenia in Iranian populations

机译：脯氨酸脱氢酶（PRODH）基因多态性以及伊朗人群中精神分裂症的风险

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Schizophrenia is a highly heritable mental disorder which can be occurred as a result of mutations or single nucleotide polymorphisms (SNPs) in various genes. Proline dehydrogenase ( PRODH ) gene is one of the most important genes which can be associated with increased risk of schizophrenia in several populations. Here, we considered the effect of PRODH gene polymorphisms on the incidence of schizophrenia in Iranian populations. This study was done using the analysis of 3 SNPs markers, including G1496A, G758A and C1482T. Molecular analysis was performed on 263 schizophrenic patients and 278 healthy individuals (control group). These examinations were executed by PCR-based restriction fragment length polymorphism (RFLP) technique. Statistical analysis was performed by SPSS software (16.0). Our findings showed that G1496A and C1482T polymorphisms in patients were significantly higher than controls and there were meaningful correlations between the occurrence of these polymorphisms and schizophrenia in the population ( P 0.001). However, there was no significant relationship between G758A in the PRODH gene and schizophrenia. Haplotype analysis showed that AAT, AAC and GAT blocks (variation alleles are bold) had significant correlations with schizophrenia. PRODH gene can be considered as one of the important genes involved in schizophrenia development among the Iranian population.
机译：精神分裂症是一种高度遗传的精神障碍，其可以在各种基因中的突变或单核苷酸多态性（SNP）中发生。脯氨酸脱氢酶（PRODH）基因是最重要的基因之一，可以与几种群体中精神分裂症的风险增加有关。在这里，我们认为PRESH基因多态性对伊朗人群精神分裂症发病率的影响。本研究是使用3个SNP标记的分析完成，包括G1496A，G758A和C1482T。在263例精神分裂症患者和278名健康个体（对照组）上进行分子分析。通过基于PCR的限制性片段长度多态性（RFLP）技术来执行这些检查。 SPSS软件（16.0）执行统计分析。我们的研究结果表明，患者的G1496A和C1482T多态性显着高于对照，并且在群体中存在这些多态性和精神分裂症之间存在有意义的相关性（P <0.001）。然而，P758A在ProDH基因和精神分裂症中没有显着的关系。单倍型分析表明，AAT，AAC和GAT嵌段（变异等位基因是粗体）与精神分裂症有显着相关性。 PRODH基因可被认为是伊朗人口中有精神分裂症发展的重要基因之一。

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