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首页> 外文期刊>Ukrainian Biochemical Journal >Hypertriglyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients
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Hypertriglyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients

机译：高甘油脂血症与高危高血压患者的心血管事件和特定合并症的长期风险有关

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Although hypertriglyceridemia (HTG) frequently occurs in hypertensive patients and may increase cardiovascular risk, the need for and manner of its reduction remain controversial. The objectives of this study were to compare lipid profiles, parameters of glucose homeostasis, comorbidity, and 5-year survival without cardiovascular events in very high-risk hypertensive (VHRH) patients with and without HTG, who received moderate intensity atorvastatin therapy. After initial assessment, 107 VHRH subjects were divided into two groups, i.e., without ( n = 49) and with HTG ( n = 58). During observation once annually patients were interviewed about prior hospitalizations with further screening for diabetes. Combined endpoint included hospitalization due acute myocardial infarction, decompensated heart failure, stroke or death. Survival was analyzed by Kaplan-Meier’s method. Nonparametric methods were used for statistical analysis. Higher median values of logarithmic value of triglycerides-to-HDL-cholesterol ratio, lipid accumulation product, fasting insulin, and HOMA index were observed in group 2 ( P 0.002) that reflect predominance of small dense LDL particles, ectopic lipid deposition and insulin resistance. Patients with HTG more commonly had type 2 diabetes (58.6% vs 34.5%, including first-detected cases during initial assessments and observation, P = 0.02), liver steatosis (81.0% vs 55.1%, P = 0.006), and lithogenic gallbladder disorders (55.2% vs 34.7%, P =0.05). Women with HTG frequently had a history of hysterovariectomy (55.2% vs 19.0%, Р = 0.018). Despite long-term statin therapy, they often failed to reach recommended LDL-C targets and had worse survival due to significantly higher incidence of combined endpoint (39.6% vs 22.4%, P = 0.027). Further studies are necessary to find safe and effective strategy for secondary prevention in this population.
机译：虽然过度甘油脂血症（HTG）经常发生在高血压患者中，但可能会增加心血管风险，但减少的需求和方式仍然存在争议。本研究的目的是比较脂质谱，葡萄糖稳态，合并症和5年生存的参数，而没有心血管事件，在非常高危的高血压（VHRH）患者中，没有HTG，他们接受了中度强度阿托伐他汀治疗。初始评估后，将107个VHRH受试者分为两组，即没有（n = 49）和HTG（n = 58）。在观察期间，每年一次患者接受了关于先前住院治疗的，并进一步筛查糖尿病。结合终点包括急性心肌梗死，失代偿的心力衰竭，中风或死亡。 Kaplan-Meier的方法分析了生存。非参数方法用于统计分析。在第2组（P <0.002）中观察到甘油三酯至HDL-胆固醇比，脂质累积产物，空腹胰岛素和HOMA指数的较高中值值，反映了小致密LDL颗粒，异位脂质沉积和胰岛素的优势抵抗性。 HTG的患者更常见于2型糖尿病（58.6％vs 34.5％，包括在初步评估和观察期间的一定检测病例，P = 0.02），肝脏脂肪变性（81.0％Vs 55.1％，p = 0.006）和岩性胆囊疾病（55.2％vs 34.7％，p = 0.05）。 HTG的妇女经常有一个血吸虫切除术的历史（55.2％Vs 19.0％，р= 0.018）。尽管他汀类药物治疗长期，但它们往往未能达到推荐的LDL-C目标，并且由于组合终点的发病率明显较高（39.6％，P = 0.027）。进一步的研究是为了寻找该人群中的二级预防的安全有效的策略。

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