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首页> 外文期刊>Ukrainian Biochemical Journal >The effect of N-stearoylethanolamine on the lipid composition of the rat testes and testosterone level during the early stages of streptozotocin-?nduced diabetes
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The effect of N-stearoylethanolamine on the lipid composition of the rat testes and testosterone level during the early stages of streptozotocin-?nduced diabetes

机译：N-硬脂酰乙醇胺对链脲佐菌素糖尿病早期阶段的大鼠睾丸脂质组合物对大鼠睾酮水平的影响

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Diabetes is a metabolic disorder with multiorgan complications, including reproductive system dysfunction where lipid imbalance of germ cells play an important role. N-stearoylethanolamine (NSE) shows a modulatory effect on the lipid composition under different pathologies. Therefore, the aim of our study was to investigate the NSE effect on the testes lipid composition and testosterone level in plasma of diabetic rats. Diabetes was induced in Sprague-Dawley rats by a single streptozotocin injection (50 mg/kg). Animals with glucose levels of 8-12 mmol/l were further selected. NSE was administrated to rats (50 mg/kg) for 10 days at 1.5 months after the streptozotocin injection. The rat testes were used for lipid analysis, namely, phospholipid level, fatty acid methyl esters and plasma testosterone estimation. NSE administration to diabetic rats triggered normalization of total and individual phospholipid content, as well as composition of free and phospholipids fatty acids in the rat testes. In addition, the testosterone content showed a slight increase under the action of NSE. Our results showed that the early stages of diabetes caused destructive changes in rat testes that may induce a decrease in future testicular function. NSE administration to diabetic rats normalized the lipid content of rat testes and was correlated with an increased testosterone level. NSE induced the restoration of testes structure and function during the early stages of streptozotocin-?nduced diabetes in rats.
机译：糖尿病是一种具有多米测并发症的代谢障碍，包括生殖系统功能障碍，毒细胞的脂质不平衡起着重要作用。 N-硬脂酰乙醇胺（NSE）显示了对不同病理下脂质组合物的调节作用。因此，我们的研究目的是研究糖尿病大鼠血浆中脂质组合物和睾酮水平的脂质组合物和睾酮水平的目的。通过单链脲佐菌素注射（50mg / kg），在Sprague-Dawley大鼠中诱导糖尿病。进一步选择具有8-12mmol / L的葡萄糖水平的动物。在链脲佐菌素注射后1.5个月后，NSE被施入大鼠（50 mg / kg）10天。大鼠试验用于脂质分析，即磷脂水平，脂肪酸甲酯和血浆睾酮估计。 NSE给予糖尿病大鼠的助剂触发总磷脂含量的标准化，以及大鼠睾丸中的游离和磷脂脂肪酸的组成。此外，睾酮含量显示在NSE的作用下略有增加。我们的研究结果表明，糖尿病的早期阶段导致大鼠睾丸的破坏性变化可能会导致未来睾丸功能减少。 NSE施用给糖尿病大鼠归一化大鼠睾丸脂质含量，并与睾酮水平增加相关。 NSE诱导恢复睾丸结构和功能期间的糖尿病患者在大鼠中的糖尿病的早期阶段。

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