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首页> 外文期刊>Pharmacology and Toxicology: An International Journal >Streptozotocin- and alloxan-induced diabetes modifies total plasma and lipoprotein lipid concentration and composition without altering cholesteryl ester transfer activity.
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Streptozotocin- and alloxan-induced diabetes modifies total plasma and lipoprotein lipid concentration and composition without altering cholesteryl ester transfer activity.

机译：链脲佐菌素和四氧嘧啶诱导的糖尿病可改变血浆和脂蛋白脂质的总浓度和组成，而不会改变胆固醇酯的转移活性。

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The objectives of this study were to determine the total plasma and lipoprotein lipid concentration and composition and cholesteryl ester transfer activity in two diabetic animal models (alloxan-induced diabetes in rabbits and streptozotocin-induced diabetes in rats). Furthermore, we wanted to determine if the severity of diabetes influences lipoprotein lipid profiles and cholesteryl ester transfer activity. Rats and rabbits were randomly divided into non-diabetic and diabetic groups. Rats were administered either 55 mg/kg or 100 mg/kg of streptozotocin intravenously through the tail vein, while rabbits were administered 100 mg/kg or 200 mg/kg of alloxan intravenously through the marginal ear vein under light anesthesia. Hyperglycaemia was tested for at 48 hr following the doses. Total and lipoprotein cholesterol and triglyceride concentrations using enzymatic kits and cholesteryl ester transfer activity from low-density lipoproteins to high-density lipoproteins using 3H-cholesteryl ester incorporated into low-density lipoproteins were determined. Elevations in both total and lipoprotein cholesterol and triglyceride concentrations and alterations in lipoprotein lipid composition are observed following the onset of drug-induced diabetes in rats and rabbits compared to non-diabetics. However, these findings were observed only in animals administered the higher streptozotocin and alloxan dose. Furthermore, cholesteryl ester transfer from low-density lipoproteins to high-density lipoproteins is not significantly different in drug-induced diabetic compared to non-diabetic rats and rabbits, regardless of which streptozotocin and alloxan dose was used. These findings suggest that difference in lipoprotein lipid concentration and composition as a result of drug-induced diabetes is independent of cholesteryl ester transfer activity in both rats and rabbits. Furthermore, diabetic severity may influence lipoprotein metabolism in these animal models.
机译：这项研究的目的是确定两种糖尿病动物模型（兔子的四氧嘧啶引起的糖尿病和大鼠的链脲佐菌素引起的糖尿病）的总血浆和脂蛋白脂质浓度，组成和胆固醇酯转移活性。此外，我们想确定糖尿病的严重程度是否影响脂蛋白脂质谱和胆固醇酯转移活性。将大鼠和兔子随机分为非糖尿病和糖尿病组。在轻度麻醉下，通过尾静脉静脉给予大鼠55 mg / kg或100 mg / kg链脲佐菌素，而兔则通过边缘耳静脉静脉给予100 mg / kg或200 mg / kg的四氧嘧啶。给药后48小时测试高血糖。使用酶试剂盒测定总和脂蛋白胆固醇和甘油三酸酯的浓度，并使用掺入低密度脂蛋白中的3H-胆固醇酯测定胆固醇酯从低密度脂蛋白到高密度脂蛋白的转移活性。与非糖尿病患者相比，在大鼠和兔子中药物诱发的糖尿病发作后，观察到总胆固醇和脂蛋白胆固醇，甘油三酸酯的浓度升高以及脂蛋白脂质组成的变化。但是，这些发现仅在使用较高链脲佐菌素和四氧嘧啶剂量的动物中观察到。此外，无论使用何种链脲佐菌素和四氧嘧啶剂量，与非糖尿病大鼠和兔子相比，药物诱导的糖尿病患者中胆固醇酯从低密度脂蛋白向高密度脂蛋白的转移没有显着差异。这些发现表明，在药物诱导的糖尿病中，脂蛋白脂质浓度和组成的差异与大鼠和兔子的胆固醇酯转移活性无关。此外，糖尿病严重程度可能会影响这些动物模型中的脂蛋白代谢。

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