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Biopolymers 2019 Development of a Novel Polymer-Based mRNA Coating for Surgical Suture to Enhance Wound Healing - Antonia Link-University Hospital Tuebingen

机译:生物聚合物2019开发用于手术缝合线的新型聚合物基mRNA涂层,以增强伤口愈合 - 安东尼亚联盟大学医院Tuebingen

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In industrialized nations, the incidence of obesity andtype II diabetes continues to increase as society simultaneouslygrows older. In Germany alone, 2.5% of the population suffersfrom chronic wounds with rising tendencies. Furthermore,chronic wounds are, on the one hand, a major burden for theperson concerned and, on the other hand, they pose a socio-economic challenge: About 2% of the health budget must beraised each year to treat poorly healing wounds. Therefore, inorder to cope with the enormous financial burden, newstrategies must be developed for achieving rapid and completewound healing. Moreover, wound healing is a complex three-stage process mediated by a large number of molecules such asdifferent enzymes, cytokines, and growth factors. Since theprocess of wound healing is determined by the nature of thewound, the healing prospects are best with smooth and closelyadjacent wound edges. Therefore, surgical sutures are used forwound closure to achieve this state whenever tissue separationoccurs due to an incision, puncture, abrasion, or other injuries.
机译:在工业化国家,肥胖症的发病率为Andtype II糖尿病仍然随着年龄较大的同时扩大而继续增加。仅在德国,2.5%的人口患有慢性伤口,趋势上升。此外,一方面,慢性伤口是有关人员的重大负担,另一方面,他们构成了社会经济挑战:每年约有2%的健康预算必须释放,以治疗愈合良好的愈合伤口。因此,为了应对巨大的财政负担,必须制定新的统筹,以实现快速和完成愈合。此外,伤口愈合是由大量分子介导的复杂的三阶段过程,例如这种酶,细胞因子和生长因子。由于伤口愈合的处理是由Thewound的性质决定的,因此愈合前景最适合使用光滑,更紧密的伤口边缘。因此,每当组织分离,由于切口,穿刺,磨损或其他损伤时,手术缝线都被剥离闭合以实现这种状态。

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    《Polymer Sciences》 |2020年第2期|共2页
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    Antonia Link;

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