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首页> 外文期刊>The Indian journal of medical research >Trends & treatment outcomes of multidrug-resistant tuberculosis in Delhi, India (2009-2014): A retrospective record-based study
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Trends & treatment outcomes of multidrug-resistant tuberculosis in Delhi, India (2009-2014): A retrospective record-based study

机译：德里德里多药抗性结核病趋势与治疗结果（2009 - 2014年）：基于回顾的记录研究

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Background & objectives: The increase in the burden of multidrug-resistant tuberculosis (MDR-TB) is a matter of grave concern. The present study was undertaken to describe MDR-TB treatment outcome trends in Delhi and their epidemiological correlates, to assess the adequacy of treatment records and to also generate evidence towards influencing and improving practices related to the MDR-TB control programme. Methods: A retrospective record-based study (2009-2014) was conducted in three major drug resistance TB treatment centres of Delhi. Treatment outcomes and adverse effects were extracted from the existing programme records including patients' treatment cards and laboratory registers. Results: A total of 2958 MDR-TB patients were identified from the treatment cards, of whom 1749 (59.12%) were males. The mean (±standard deviation) age was 30.56±13.5 years. Favourable treatment outcomes were reported in 1371 (53.28%) patients, but they showed a declining trend during the period of observation. On binomial logistic regression analysis, patients with age ≥35 yr, male sex and undernourishment (body mass index 18.5) at the time of treatment initiation had a significantly increased likelihood of unfavourable MDR-TB treatment outcome (P 0.001). Interpretation & conclusions: The study showed an increasing burden of MDR-TB patients, especially in the young population with increased risk of transmission posing a major challenge in achieving TB elimination targets.
机译：背景与目标：多药抗性结核病（MDR-TB）的负担的增加是一个严重关切的问题。本研究旨在描述德里及其流行病学相关的MDR-TB治疗结果趋势，以评估治疗记录的充分性，并为影响和改善与MDR-TB控制计划相关的做法产生证据。方法：在三种主要耐药性TB治疗中心进行了基于回顾的基于记录的研究（2009-2014）。从现有的计划记录中提取治疗结果和不良反应，包括患者治疗卡和实验室登记。结果：共有2958名MDR-TB患者从治疗卡中鉴定，其中1749名（59.12％）是男性。平均（标准偏差）年龄为30.56±13.5岁。 1371年（53.28％）患者报告了有利的治疗结果，但它们在观察期间表现出下降的趋势。关于二项式物流回归分析，治疗开始时≥35年龄≥35岁，男性性别和营养不良（体重指数<18.5）的患者显着增加了不利的MDR-TB治疗结果的可能性（P <0.001）。解释与结论：该研究表明，MDR-TB患者的负担越来越大，特别是在年轻人中，随着传播风险增加，在实现结核病淘汰目标方面发挥着重大挑战。

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