The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells

Tovah Wolf; Scott R Baier; Janos Zempleni*

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The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells

机译：牛奶外泌体的肠道输送是通过人结肠癌Caco-2细胞和大鼠小肠IEC-6细胞的内吞作用介导的

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Background: MicroRNAs play essential roles in gene regulation. A substantial fraction of microRNAs in tissues and body fluids is encapsulated in exosomes, thereby conferring protection against degradation and a pathway for intestinal transport. MicroRNAs in cow milk are bioavailable in humans.

机译：背景：MicroRNA在基因调节中起重要作用。组织和体液中的大部分MicroRNA被包封在外泌体中，从而促使防止降解和用于肠道输送的途径。牛奶中的microRNA是人类生物利用。

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《The Journal of Nutrition: Official Organ of the American Institute of Nutrition》 |2015年第10期|共6页
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Tovah Wolf; Scott R Baier; Janos Zempleni*;
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1. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells [J] . Ha Jung-Heun, Doguer Caglar, Collins James F. Metallomics. integrated biometal science . 2016,第9期

机译：敲低运输铜的ATPase 1（Atp7a）会损害全分化大鼠（IEC-6）和人（Caco-2）肠上皮细胞中的铁通量
2. Human Milk Oligosaccharides Mediate the Crosstalk Between Intestinal Epithelial Caco-2 Cells and Lactobacillus PlantarumWCFS1in an I n Vitro Model with Intestinal Peristaltic Shear Force [J] . Chunli Kong, Lianghui Cheng, Guido Krenning, The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 2020,第8期

机译：人乳寡糖介导肠上皮Caco-2细胞之间的串扰和<斜杆菌>植物杆菌（Plantarum）和肠道蠕动剪切力的I <粗体> n vold>模型
3. Comparison of the Efficacy of Alpha-Lactalbumin from Equine, Bovine, and Human Milk in the Growth of Intestinal IEC-6 Cells [J] . Xijier, Yuki Mori, Mayuko Fukuoka Bioscience, Biotechnology, and Biochemistry . 2012,第4期

机译：马，牛和人乳中的α-乳清蛋白在肠道IEC-6细胞生长中的功效比较
4. Regulation of the human taurine transporter by TNF-a and an anti-inflammatory function of taurine in human intestinal Caco-2 cells [C] . Tetsunosuke Mochizuki, Hideo Satsu, Tomoko Nakano, International Conference on Food Factors . 2004

机译：通过TNF-A和人肠道Caco-2细胞的牛磺酸的抗炎功能调节人牛磺酸转运蛋白
5. Lovastatin, delta-tocotrienol and genistein supress the proliferation of human Caco-2 colon carcinoma cells. [D] . Parvin, Hosne Ara. 2005

机译：洛伐他汀，δ-生育三烯酚和染料木黄酮抑制人Caco-2结肠癌细胞的增殖。
6. The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells [O] . Tovah Wolf, Scott R Baier, Janos Zempleni -1

机译：牛乳外泌体的肠道运输是由人类结肠癌Caco-2细胞和大鼠小肠IEC-6细胞的内吞作用介导的。
7. Monocarboxylate Transporter-Mediated Transport of γ-Hydroxybutyric Acid in Human Intestinal Caco-2 Cells [O] . Lam, Wing Ki, Felmlee, Melanie A., Morris, Marilyn E. 2009

机译：单羧酸盐转运体介导的人小肠Caco-2细胞中γ-羟基丁酸的转运

The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells

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