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首页> 外文期刊>The Journal of toxicological sciences >Photodegradation of pharmaceuticals in the aquatic environment by sunlight and UV-A, -B and -C irradiation
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Photodegradation of pharmaceuticals in the aquatic environment by sunlight and UV-A, -B and -C irradiation

机译：通过阳光和UV-A，-B和-C辐照将药物的光降解

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In order to investigate the effect of sunlight on the persistence and ecotoxicity of pharmaceuticals contaminating the aquatic environment, we exposed nine pharmaceuticals (acetaminophen (AA), amiodarone (AM), dapsone (DP), dexamethasone (DX), indomethacin (IM), naproxen (NP), phenytoin (PH), raloxifene (RL), and sulindac (SL)) in aqueous media to sunlight and to ultraviolet (UV) irradiation at 254, 302 or 365 nm (UV-C, UV-B or UV-A, respectively). Degradation of the pharmaceuticals was monitored by means of high-performance liquid chromatography (HPLC). Sunlight completely degraded AM, DP and DX within 6 hr, and partly degraded the other pharmaceuticals, except AA and PH, which were not degraded. Similar results were obtained with UV-B, while UV-A was less effective (both UV-A and -B are components of sunlight). All the pharmaceuticals were photodegraded by UV-C, which is used for sterilization in sewage treatment plants. Thus, the photodegradation rates of pharmaceuticals are dependent on both chemical structure and the wavelength of UV exposure. Toxicity assay using the luminescent bacteria test (ISO11348) indicated that UV irradiation reduced the toxicity of some pharmaceuticals to aquatic organisms by decreasing their amount (photodegradation) and increased the toxicity of others by generating toxic photoproduct(s). These results indicate the importance of investigating not only parent compounds, but also photoproducts in the risk assessment of pharmaceuticals in aquatic environments.
机译：为了探讨阳光对污染水生环境的药物持续和生态毒性的影响，我们暴露了九种药物（乙酰氨基酚（AA），胺碘酮（AM），氨基酮（DP），地塞米松（DX），Indomethacin（IM），在含水介质中的萘普生（NP），苯妥林（pH），雷洛昔芬（R1）和舒林酰基（SL））和254,302或365nm（UV-C，UV-B或UV的紫外（UV）照射 - 分别））。通过高效液相色谱（HPLC）监测药物的降解。阳光在6小时内完全降解AM，DP和DX，并且部分地降解了除AA和pH之外的其他药物，它们不会降低。用UV-B获得类似的结果，而UV-A效果较低（UV-A和-B两者是阳光的组分）。所有药物都是通过UV-C光降解的，其用于污水处理厂的灭菌。因此，药物的光降解速率取决于化学结构和UV暴露的波长。使用发光细菌试验（ISO11348）的毒性测定表明，UV辐射通过降低其量（光降解）并通过产生有毒光调节来增加一些药物对水生生物的毒性。通过产生有毒光调节，增加了他人的毒性。这些结果表明，不仅对母体化合物进行调查的重要性，而且还表明了水生环境中药物风险评估中的光调节。

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