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首页> 外文期刊>The Journal of toxicological sciences >Photodegradation of pharmaceuticals in the aquatic environment by sunlight and UV-A, -B and -C irradiation.
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Photodegradation of pharmaceuticals in the aquatic environment by sunlight and UV-A, -B and -C irradiation.

机译：阳光和UV-A，-B和-C辐照在水生环境中对药物的光降解作用。

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In order to investigate the effect of sunlight on the persistence and ecotoxicity of pharmaceuticals contaminating the aquatic environment, we exposed nine pharmaceuticals (acetaminophen (AA), amiodarone (AM), dapsone (DP), dexamethasone (DX), indomethacin (IM), naproxen (NP), phenytoin (PH), raloxifene (RL), and sulindac (SL)) in aqueous media to sunlight and to ultraviolet (UV) irradiation at 254, 302 or 365 nm (UV-C, UV-B or UV-A, respectively). Degradation of the pharmaceuticals was monitored by means of high-performance liquid chromatography (HPLC). Sunlight completely degraded AM, DP and DX within 6 hr, and partly degraded the other pharmaceuticals, except AA and PH, which were not degraded. Similar results were obtained with UV-B, while UV-A was less effective (both UV-A and -B are components of sunlight). All the pharmaceuticals were photodegraded by UV-C, which is used for sterilization in sewage treatment plants. Thus, the photodegradation rates of pharmaceuticals are dependent on both chemical structure and the wavelength of UV exposure. Toxicity assay using the luminescent bacteria test (ISO11348) indicated that UV irradiation reduced the toxicity of some pharmaceuticals to aquatic organisms by decreasing their amount (photodegradation) and increased the toxicity of others by generating toxic photoproduct(s). These results indicate the importance of investigating not only parent compounds, but also photoproducts in the risk assessment of pharmaceuticals in aquatic environments.
机译：为了研究阳光对污染水生环境的药物的持久性和生态毒性的影响，我们暴露了九种药物（对乙酰氨基酚（AA），胺碘酮（AM），氨苯砜（DP），地塞米松（DX），消炎痛（IM），萘普生（NP），苯妥英钠（PH），雷洛昔芬（RL）和舒林酸（SL））在水性介质中对阳光和254、302或365 nm的紫外线（UV-C，UV-B或UV）照射-A）。药物的降解通过高效液相色谱法（HPLC）进行监测。阳光在6小时内完全降解了AM，DP和DX，部分降解了除AA和PH以外的其他未降解的药物。使用UV-B可获得类似的结果，而UV-A效果较差（UV-A和-B均为阳光的成分）。所有药物均通过UV-C光降解，该UV-C用于污水处理厂的灭菌。因此，药物的光降解速率取决于化学结构和紫外线照射的波长。使用发光细菌测试（ISO11348）进行的毒性试验表明，紫外线照射通过减少其数量（光降解）来降低某些药物对水生生物的毒性，并通过产生有毒的光产物来增加其他药物的毒性。这些结果表明，在水生环境中对药物进行风险评估时，不仅要研究母体化合物，而且还要研究光产品，这一点非常重要。

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