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首页> 外文期刊>Thoracic cancer. >Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study
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Choice of surgical procedure – lobectomy, segmentectomy, or wedge resection – for patients with stage T1‐2N0M0 small cell lung cancer: A population‐based study

机译：手术程序的选择 - 肺叶切除术，分段切除术或楔形切除 - 用于阶段T1-2N0M0小细胞肺癌的患者：基于人群的研究

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To date, few studies have evaluated the impact of lobectomy versus sublobar resection for early small cell lung cancer (SCLC). We investigated the survival rates of patients with pathological stage T1-2N0M0 SCLC who underwent lobectomy or sublobar resection. We identified 548 SCLC patients in the Surveillance, Epidemiology, and End Results database who underwent lobectomy or sublobar resection. Propensity score matching (PSM) and Cox regression analysis were used to adjust for baseline characteristics. The three-year overall survival (OS) of patients treated with lobectomy (n?=?376, 60%) was significantly higher than those treated with sublobar resection (n?=?172, 38%). PSM and Cox multivariable analysis further confirmed this result (hazard ratio [HR] 0.543, 95% confidence interval [CI] 0.421-0.680; P??0.001). The three-year OS of patients treated with segmentectomy (n?=?24, 54%) and wedge resection (n?=?148, 36%) was not significantly different (HR 0.639, 95% CI 0.393-1.039; P?=?0.071). Based on PSM analysis, segmentectomy conferred a superior survival advantage to patients relative to wedge resection (HR 0.466, 95% CI 0.221-0.979; P?=?0.040). Lobectomy correlated with superior survival. For patients in which lobectomy is unsuitable, prognosis following segmentectomy appears to be better than after wedge resection. ? 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
机译：迄今为止，很少有研究评估了Lobectomy与苏布罗巴尔切除早期小细胞肺癌（SCLC）的影响。我们研究了术后病理阶段T1-2N0M0 SCLC的患者的存活率，他们接受了肺切除术或副伞形切除术。我们鉴定了548名SCLC患者在监测，流行病学和最终结果数据库中，他们接受了肺切除术或索伯巴骨切除术。倾向得分匹配（PSM）和COX回归分析用于调整基线特性。用肺切除术治疗的患者的三年整体存活率（N？= 376,60％）显着高于索伯巴尔切除术治疗的患者（N？= 172,38％）。 PSM和COX多变量分析进一步证实了该结果（危险比[HR] 0.543，95％置信区间[CI] 0.421-0.680; p？<0.001）。用细胞切除术治疗的患者的三年OS（n？= 24,54％）和楔形切除（n？= 148,36％）没有显着差异（HR 0.639,95％CI 0.393-1.039; p？ =？0.071）。基于PSM分析，分段切除术对患者相对于楔切除术（HR 0.466,95％CI 0.221-0.979; P？= 0.040）赋予患者优异的存活优势。肺叶形成与优异的存活率相关。对于肺叶切除术不适合的患者，在楔切除后的分段切除术后预后似乎更好。 ？ 2018年的作者。中国肺部肿瘤集团和约翰瓦里和儿子澳大利亚发表的胸癌

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