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首页> 外文期刊>Thoracic cancer. >Quantitative severity of pulmonary emphysema as a prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer
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Quantitative severity of pulmonary emphysema as a prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer

机译：肺肺部的定量严重程度作为手术切除非小细胞肺癌患者复发的预后因素

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Pulmonary emphysema is a major component of chronic obstructive pulmonary disease and lung cancer. However the prognostic significance of quantitative emphysema severity in patients with lung cancer is unclear. We analyzed whether numerical emphysema value is a prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer. We quantified emphysema severity of the whole lung and regional lobes in 45 patients (mean age 68.0 years) using an automated chest computed tomography-based program. Predictive factors for recurrence were investigated using a Cox proportional hazards model. Recurrence-free and overall survival was compared after dichotomization of patients according to whole lung emphysema severity. The mean percentage emphysema ratio of the whole lung was 1.21?±?2.04. Regional lobar emphysema severity was highest in the right middle lobe (1.93?±?0.36), followed by right upper (1.35?±?2.50), left upper (1.34?±?2.12), left lower (1.05?±?2.52), and right lower (0.78?±?2.28) lobes. The low severity group showed significantly longer overall survival compared to the high severity group (log-rank test, P?=?0.018). Quantitative emphysema severity of the whole lung (hazard ratio 1.36; 95% confidence interval 1.0-1.73) and stage III (hazard ratio 6.17; 95% confidence interval 1.52-25.0) were independent predictors of recurrence after adjusting for age, gender, smoking status, and forced expiratory volume in one second. The severity of whole lung emphysema was independently associated with recurrence. Patients with non-small cell lung cancer and marginal pulmonary emphysema at lower severity survive longer after curative-intent surgery. ? 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
机译：肺气肿是慢性阻塞性肺病和肺癌的主要组成部分。然而，肺癌患者定量肺气肿严重程度的预后意义尚不清楚。我们分析了数值肺气肿是否是手术切除非小细胞肺癌患者复发的预后因素。我们使用自动胸部计算机断层扫描的计划量化了45名患者的整个肺和区域裂片的肺气肿严重程度。使用Cox比例危害模型研究了复发的预测因素。根据整个肺部肺气肿严重程度在患者的二分层后比较无复发和整体存活。整个肺的平均百分比柔软物率为1.21？±2.04。右侧叶片（1.93？±0.36），左上（1.35？±2.5​​0），左上（1.34？±2.12），左上（1.05？±2.12），左上（1.05？±2.2.52） ，右下（0.78？±2.28）裂片。与高严重程度组相比，低严重程度组显着更长的整体存活率（对数秩检验，P？= 0.018）。全肺的定量肺气肿严重程度（危险比1.36; 95％置信区间1.0-1.73）和第三阶段（危险比6.17; 95％置信区间1.52-25.0）是调整年龄，性别，吸烟状态后复发的独立预测因素并且强迫呼气量一秒钟。整肺肺气肿的严重程度与复发性独立相关。非小细胞肺癌和边缘肺气肿的患者在疗效术后较低的严重程度存活地生存。 ？ 2018年的作者。中国肺部肿瘤集团和约翰瓦里和儿子澳大利亚发表的胸癌

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