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首页> 外文期刊>Theranostics >Copper Manganese Sulfide Nanoplates: A New Two-Dimensional Theranostic Nanoplatform for MRI/MSOT Dual-Modal Imaging-Guided Photothermal Therapy in the Second Near-Infrared Window
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Copper Manganese Sulfide Nanoplates: A New Two-Dimensional Theranostic Nanoplatform for MRI/MSOT Dual-Modal Imaging-Guided Photothermal Therapy in the Second Near-Infrared Window

机译：铜锰硫化物纳米板：第二近近红外窗口MRI / MSOT双型成像引导的光热疗的新型二维治疗纳米晶状体

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Multifunctional nanoplatforms with integrated diagnostic and therapeutic functions have attracted tremendous attention. Especially, the second near-infrared (NIR-II) light response-based nanoplatforms hold great potential in cancer theranostic applications, which is because the NIR-II window provides larger tissue penetration depth and higher maximum permissible exposure (MPE) than that of the well-studied first near-infrared (NIR-I) window. Herein, we for the first time present a two-dimensional (2D)-nanoplatform based on Cu2MnS2 nanoplates (NPs) for magnetic resonance imaging (MRI)/multispectral optoacoustic tomography (MSOT) dual-modal imaging-guided photothermal therapy (PTT) of cancer in the NIR-II window. Methods: Cu2MnS2 NPs were synthesized through a facile and environmentally friendly process. A series of experiments, including the characterization of Cu2MnS2 NPs, the long-term toxicity of Cu2MnS2 NPs in BALB/c nude mice, the applications of Cu2MnS2 NPs for in vitro and in vivo MRI/MSOT dual-modal imaging and NIR-II PTT of cancer were carried out. Results: The as-synthesized Cu2MnS2 NPs exhibit low cytotoxicity, excellent biocompatibility as well as high photothermal conversion efficiency (~49.38%) and outstanding photostability. Together with their good T 1-shortening effect and strong absorbance in the NIR-I and NIR-II region, the Cu2MnS2 NPs display high-contrast imaging performance both in MRI and MSOT (900 nm laser source). Moreover, the subsequent in vitro and in vivo results demonstrate that the Cu2MnS2 NPs possess excellent PTT efficacy under 1064 nm laser irradiation with a low power density (0.6 W cm-2). In addition, the detailed long-term toxicity studies further confirming the safety of Cu2MnS2 NPs in vivo . Conclusion: We have developed a new 2D Cu2MnS2 NPs as multifunctional theranostic agents for MRI/MSOT dual-modal imaging-guided PTT of cancer in the NIR-II window. Such biocompatible Cu2MnS2 NPs might provide a new perspective for exploring new 2D-based nanoplatforms with improved properties for clinical applications in the future.
机译：具有综合诊断和治疗功能的多功能纳米片引起了巨大的关注。特别地，第二近红外（NIR-II）基于光响应的纳米型纳米膜在癌症治疗应用中具有很大的潜力，这是因为NIR-II窗口提供较大的组织穿透深度和更高的最大允许曝光（MPE）研究了第一次近红外（NIR-I）窗口。在此，我们首次呈现基于Cu 2 Mns 2 纳米板（MRI）/多光谱的Cu-2 纳米板（NPS）的二维（2D）-NONOPLATFOOL光音断层扫描（MSOT）NIR-II窗口中癌症的双模成像引导的光热疗法（PTT）。方法：Cu 2 Mns 2 nps是通过容易和环保的过程合成的。一系列实验，包括Cu 2 mns 2 nps的表征，Cu 2 mns 2的长期毒性< /亚> NPS在BALB / C裸鼠中，Cu 2 Mns 2 nps在体外和体内MRI / MSOT双模态成像和NIR-II中的应用进行了癌症的ptt。结果：AS合成的Cu 2 Mns 2 nps表现出低细胞毒性，优异的生物相容性以及高光热转化效率（〜49.38％）和出色的光稳定性。与它们的良​​好T 1 - 在NIR-I和NIR-II区域中的吸光度强，CU 2 MNS 2 NPS在MRI和MSOT（900nm激光源）中显示高对比度成像性能。此外，随后的体外和体内结果表明Cu 2 Mns 2 nps具有优异的PTT功效，在1064nm激光照射下具有低功率密度（0.6W cm -2 ）。此外，详细的长期毒性研究进一步证实了Cu 2 Mns 2 nps的安全性。结论：我们开发了一种新的2D Cu 2 Mns 2 nps，作为多官能的治疗剂，用于NIR-II窗口中癌症的MRI / MSOT双模式成像引导PTT 。这种生物相容性Cu 2 Mns 2 NPS可以提供​​一种新的透视，用于探索新的基于2D的基于纳米纳薄形状，并在未来改善临床应用的性能。

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