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首页> 外文期刊>Advanced Functional Materials >Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy
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Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy

机译：硫化钽纳米片作为计算机断层扫描成像指导的组合化学光热疗法的治疗治疗纳米平台

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摘要

Near-infrared (NIR)-absorbing metal-based nanomaterials have shown tremendous potential for cancer therapy, given their facile and controllable synthesis, efficient photothermal conversion, capability of spatiotemporal-controlled drug delivery, and intrinsic imaging function. Tantalum (Ta) is among the most biocompatible metals and arouses negligible adverse biological responses in either oxidized or reduced forms, and thus Ta-derived nanomaterials represent promising candidates for biomedical applications. However, Ta-based nanomaterials by themselves have not been explored for NIR-mediated photothermal ablation therapy. In this work, an innovative Ta-based multifunctional nanoplatform composed of biocompatible tantalum sulfide (TaS2) nanosheets (NSs) is reported for simultaneous NIR hyperthermia, drug delivery, and computed tomography (CT) imaging. The TaS2 NSs exhibit multiple unique features including (i) efficient NIR light-to-heat conversion with a high photothermal conversion efficiency of 39%, (ii) high drug loading (177% by weight), (iii) controlled drug release triggered by NIR light and moderate acidic pH, (iv) high tumor accumulation via heat-enhanced tumor vascular permeability, (v) complete tumor ablation and negligible side effects, and (vi) comparable CT imaging contrast efficiency to the widely clinically used agent iobitridol. It is expected that this multifunctional NS platform can serve as a promising candidate for imaging-guided cancer therapy and selection of cancer patients with high tumor accumulation.
机译：吸收近红外（NIR）的金属基纳米材料显示出巨大的潜力，可用于癌症治疗，这是因为它们具有易于合成且可控制的合成，有效的光热转化，时空控制的药物传递能力以及固有的成像功能。钽（Ta）是生物相容性最高的金属之一，它以氧化或还原形式引起的不良生物学反应可忽略不计，因此Ta衍生的纳米材料代表了生物医学应用的有希望的候选者。然而，基于Ta的纳米材料本身尚未用于NIR介导的光热消融治疗。在这项工作中，报道了由生物相容性硫化钽（TaS2）纳米片（NSs）组成的创新的基于Ta的多功能纳米平台，用于同时进行NIR热疗，药物输送和计算机断层扫描（CT）成像。 TaS2 NS具有多种独特功能，包括（i）高效率的近红外光热转换，光热转换效率高达39％，（ii）载药量高（按重量计177％），（iii）由触发的受控药物释放NIR光线和中等酸性pH，（iv）通过增强的肿瘤血管通透性实现高肿瘤蓄积，（v）完全消融，副作用可忽略不计，（vi）CT成像的对比效果与临床上广泛使用的药物iobitridol相当。可以预期，该多功能NS平台可以作为有前景的候选者，用于影像引导的癌症治疗和高肿瘤累积的癌症患者的选择。

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  • 来源
    《Advanced Functional Materials》 |2017年第39期|1703261.1-1703261.12|共12页
  • 作者

    Liu Yanlan; Ji Xiaoyuan; Liu Jianhua; Tong Winnie W. L.; Askhatova Diana; Shi Jinjun;

  • 作者单位

    Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA|Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA|Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA|Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Jilin Univ, Hosp 2, Dept Radiol, Changchun 130041, Jilin, Peoples R China;

    Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA|Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA|Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA;

    Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA|Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA;

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  • 正文语种 eng
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  • 关键词

    cancer therapy; CT imaging; drug delivery; hyperthermia; TaS2 nanosheets;

    机译：癌症治疗;CT成像;药物输送;体温过高;TaS2纳米片;

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