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Doxorubicin-Loaded Unimolecular Micelle-Stabilized Gold Nanoparticles as a Theranostic Nanoplatform for Tumor-Targeted Chemotherapy and Computed Tomography Imaging

机译：加载的肿瘤靶向化疗和计算机断层摄影成像作为肿瘤靶向化疗和计算机断层摄像性成像的多柔比蛋白素的单分子胶片纳米粒子

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摘要

Current research is mainly trending toward addressing the development of multifunctional nanocarriers that could precisely reach disease sites, release drugs in a controlled-manner, and act as an imaging agent for both diagnosis and targeted therapy. In this study, a pH-sensitive theranostic nanoplatform as a promising dual-functional nanovector for tumor therapy and computed tomography (CT) imaging was developed. The 21-arm star-like triblock polymer of beta-cyclodextrin-{poly(epsilon-caprolactone)-poly(2-aminoethyl methacrylate)-poly[poly(ethylene glycol) methyl ether methacrylate]}(21) [beta-CD-(PCL-PAEMA-PPEGMA)(21)] with stable unimolecular micelles formed in aqueous solution was first synthesized by combined ROP with ARGET ATRP techniques and then was used as a template for fabricating gold nanoparticles (AuNPs) with uniform sizes and excellent colloidal stability in situ followed by the encapsulation of doxorubicin (DOX) with maximum entrapment efficiency up to 60% to generate the final product beta-CD-(PCL-PAEMA-PPEGMA)(21)/AuNPs/DOX. Furthermore, dissipative particle dynamics (DPD) simulations revealed further details of the formation process of unimolecular micelles and the morphologies and distributions of AuNPs and DOX. Almost 80% of DOX was released in 120 h in an acidic tumoral environment in an in vitro drug release experiment, and the experiments both in vitro and in vivo demonstrated the fact that beta-CD-(PCL-PAEMA-PPEGMA)21/AuNPs/DOX exhibited similar antitumor efficacy to free DOX and effective CT imaging performance. Therefore, we believe this structurally stable unimolecular micelle-based nanoplatform synergistically integrated with anticancer drug delivery and CT imaging capabilities hold great promise for future cancer theranostics.
机译：目前的研究主要是促进解决可以精确地达到疾病部位的多功能纳米载体的发展，以受控方式释放药物，并作为诊断和靶向治疗的成像剂。在该研究中，开发了一种pH敏感的硫氧化物纳米片，作为用于肿瘤治疗和计算机断层扫描（CT）成像的有希望的双功能纳米液。 β-环糊精的21臂星状三嵌段聚合物 - （聚（ε-己内酯） - 聚（2-氨基乙基甲基丙烯酸甲酯）-poly [聚（乙二醇）甲基醚甲基丙烯酸酯]}（21）[β-CD- （PCL-PAEMA-PPEGMA）（21）]通过将ROP组合用锻炼ATRP技术合并，用稳定的单分子胶束合成，然后用作制造金纳米颗粒（AUNP）的模板，具有均匀的尺寸和优异的胶体稳定性原位后面是多柔比蛋白（DOX）的封装，最大夹带效率高达60％，以产生最终产品β-CD-（PCL-PAEMA-PPEGMA）（21）/ AUNPS / DOX。此外，耗散粒子动力学（DPD）模拟揭示了单胶束的形成过程的进一步细节和AUNP和DOX的形态和分布。在体外药物释放实验中，近80％的DOX在120小时内在酸性肿瘤环境中释放，体外和体内的实验证明了β-CD-（PCL-PAEMA-PPEGMA）21 / AUNPS的事实/ dox表现出类似的抗肿瘤功效与免费DOX和有效的CT成像性能。因此，我们认为这种结构稳定的非分子胶束基础纳米片，与抗癌药物递送协同整合，CT成像能力对未来的癌症治疗有很大的承诺。

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  • 来源
    《Biomacromolecules》 |2017年第12期|共12页
  • 作者

    Lin Wenjing; Zhang Xiaofang; Qian Long; Yao Na; Pan Ya; Zhang Lijuan;

  • 作者单位

    South China Univ Technol Sch Chem &

    Chem Engn Guangzhou 510640 Guangdong Peoples R China;

    South China Univ Technol Sch Chem &

    Chem Engn Guangzhou 510640 Guangdong Peoples R China;

    NYU Dept Biol New York NY 10003 USA;

    South China Univ Technol Sch Chem &

    Chem Engn Guangzhou 510640 Guangdong Peoples R China;

    South China Univ Technol Sch Chem &

    Chem Engn Guangzhou 510640 Guangdong Peoples R China;

    South China Univ Technol Sch Chem &

    Chem Engn Guangzhou 510640 Guangdong Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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