...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Therapeutic advances in drug safety. >Risk of hepatotoxicity with trastuzumab emtansine in breast cancer patients: a systematic review and meta-analysis
【24h】

Risk of hepatotoxicity with trastuzumab emtansine in breast cancer patients: a systematic review and meta-analysis

机译：患有乳腺癌患者的曲妥珠单抗的肝毒性风险：系统审查和荟萃分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Trastuzumab emtansine (T-DM1) is an anti-HER2 antibody-drug conjugate indicated for the treatment of HER2-positive breast cancer. One of the most severe adverse events reported with T-DM1 is hepatotoxicity. The objective of our meta-analysis is to investigate the risk of hepatic adverse events in patients with breast cancer receiving T-DM1 compared with controls. Methods: We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) comparing T-DM1 with a control treatment in patients with HER2-positive breast cancer. Phase II/III RCTs with available event number or event rate of hepatic toxicity with an assessable sample size were included. Relative risk (RR) and corresponding 95% confidence intervals (CI) for all grade and high-grade (grade 3/4) aspartate aminotransferase (AST) and alanine aminotransferase (ALT) elevations were calculated. Results: Seven RCTs were deemed eligible and were included in the meta-analysis. The RR for all-grade AST and ALT elevations were 3.24 (95% CI 2.16–4.86; p Conclusions: Our meta-analysis demonstrates that T-DM1-based therapy is associated with an increased risk of AST and ALT elevations.
机译：背景：Trastuzumab Emtansine（T-DM1）是一种抗HER2抗体 - 药物缀合物，用于治疗HER2阳性乳腺癌。用T-DM1报道的最严重的不良事件之一是肝毒性。我们的荟萃分析的目的是探讨乳腺癌患者接受T-DM1患者肝不良事件的风险。方法：对随机临床试验（RCT）进行了系统的评价和荟萃分析，比较T-DM1与HER2阳性乳腺癌患者的对照治疗。包括可用事件编号的II / III次数或肝脏毒性事件率，具有可评估的样本量。计算所有等级和高级（3/4级）天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）升高的相对风险（RR）和相应的95％置信区间（CI）。结果：七个RCT被视为符合条件，并包含在Meta分析中。所有级AST和ALT升级的RR为3.24（95％CI 2.16-4.86; P结论：我们的META分析表明，基于T-DM1的疗法与AST和ALT升高的风险增加有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号