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首页> 外文期刊>Therapeutic advances in endocrinology and metabolism. >A review of sotagliflozin for use in type 1 diabetes
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A review of sotagliflozin for use in type 1 diabetes

机译：用于1型糖尿病的Sotagliflozin综述

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Type 1 diabetes is a challenging disease that is largely managed with the use of insulin. The risk of hypoglycemia, side effects of weight gain, and high glucose variability associated with insulin use have prompted researchers to explore additional therapies to treat this condition. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of medications that lower glucose in type 2 diabetes patients independent of insulin action, and have been studied for use in the type 1 diabetes population. Sotagliflozin is an SGLT2 inhibitor that demonstrates a unique binding affinity for the SGLT1 receptor. A total of three phase III clinical trials (inTandem1, inTandem2, and inTandem3) were conducted to evaluate the safety and efficacy of sotagliflozin in type 1 diabetes. A modest hemoglobin A1C reduction of 0.3–0.4% was observed, with secondary benefits of reduced glucose variability, reduced insulin dosage, and positive weight loss effects. Overall there was a reduction in the risk of severe hypoglycemia with sotagliflozin, but a higher rate of ketone formation and risk of diabetic ketoacidosis was observed, along with increased mycotic infections and volume depletion effects.
机译：1型糖尿病是一种挑战性的疾病，主要用于使用胰岛素。低血糖，重量增益的副作用和与胰岛素使用相关的高葡萄糖可变性的风险促使研究人员探索治疗这种情况的额外疗法。葡萄糖Cotroangerper 2（SGlT2）抑制剂是一类药物，其在2型糖尿病患者中降低葡萄糖，与胰岛素作用无关，并已研究用于1型糖尿病群。 Sotagliflozin是一种SGLT2抑制剂，其证明了对SGLT1受体的独特结合亲和力。进行了共有三种第III期临床试验（Intandem1，IntandeM2和Intandem3），以评估Sotagliflozin在1型糖尿病中的安全性和功效。观察到0.3-0.4％的适度血红蛋白A1C降低，具有降低的葡萄糖可变性，降低胰岛素剂量和阳性体重减轻效应的二次益处。总体而言，随着Sotagliflozin的严重低血糖的风险降低，但观察到酮的形成和糖尿病酮症病的风险以及增加的毒性感染和体积耗尽效应。

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