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首页> 外文期刊>Translational psychiatry. >Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology
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Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology

机译：22Q11.2在22 Q11.2中儿童，青春期和成年期的认知缺陷缺失综合征和与精神病理学相关联

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22q11.2 Deletion Syndrome (22q11.2DS) is associated with high risk of psychiatric disorders and cognitive impairment. It remains unclear to what extent key cognitive skills are associated with psychopathology, and whether cognition is stable over time in 22q11.2DS. 236 children, adolescents and adults with 22q11.2DS and 106 typically developing controls were recruited from three sites across Europe. Measures of IQ, processing speed, sustained attention, spatial working memory and psychiatric assessments were completed. Cognitive performance in individuals was calculated relative to controls in different age groups (children (6-9 years), adolescents (10-17 years), adults (18+ years)). Individuals with 22q11.2DS exhibited cognitive impairment and higher rates of psychiatric disorders compared to typically developing controls. Presence of Autism Spectrum Disorder symptoms was associated with greater deficits in processing speed, sustained attention and working memory in adolescents but not children. Attention deficit hyperactivity disorder in children and adolescents and psychotic disorder in adulthood was associated with sustained attention impairment. Processing speed and working memory were more impaired in children and adults with 22q11.2DS respectively, whereas the deficit in sustained attention was present from childhood and remained static over developmental stages. Psychopathology was associated with cognitive profile of individuals with 22q11.2DS in an age-specific and domain-specific manner. Furthermore, magnitude of cognitive impairment differed by developmental stage in 22q11.2DS and the pattern differed by domain.
机译：22Q11.2删除综合征（22Q11.2DS）与精神疾病和认知障碍的高风险有关。它仍不清楚关键认知技能与精神病理学相关的程度，以及认知是否随着时间的推移在22Q11.2DS中稳定。 236名儿童，青少年和成人22Q11.2DS和106次典型开发控制被招募了欧洲三个地点。完成了智商，加工速度，持续关注，空间工作记忆和精神病学评估的措施。相对于不同年龄组（儿童（6-9岁），青少年（10-17岁），成年人（18岁以上）的对照计算个体中的认知性能。与典型的发展控制相比，具有22Q11.2DS的个人表现出认知障碍和更高的精神疾病率。自闭症谱系障碍的存在症状与加工速度，持续的青少年的持续关注和工作记忆更大的缺陷相关，但不是儿童。儿童和青少年的注意力缺陷多动障碍和成年人的精神病障碍与持续关注障碍有关。在儿童和成年人中，分别在22Q11.2DS的儿童和成人中，处理速度和工作记忆分别受到损害，而持续关注的赤字出现在儿童时期，并且在发育阶段保持静态。精神病理学与年龄特异性和域名特定方式的个人的认知概况与22Q11.2DS的认知概况有关。此外，认知损伤的幅度在22Q11.2DS中的发育阶段不同，并且域的模式不同。

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