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首页> 外文期刊>Translational psychiatry. >The efficacy and safety of omega-3 fatty acids on depressive symptoms in perinatal women: a meta-analysis of randomized placebo-controlled trials
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The efficacy and safety of omega-3 fatty acids on depressive symptoms in perinatal women: a meta-analysis of randomized placebo-controlled trials

机译：Omega-3脂肪酸对围产期女性抑郁症状的疗效和安全性：随机安慰剂对照试验的荟萃分析

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Omega-3 fatty acids (FA), as a nutrient, has been proven effective in major depressive disorder (MDD), however, the results of monotherapy in perinatal depression (PND) remain unclear. To examine the efficacy and safety of omega-3 fatty acids (FA) monotherapy for perinatal depression (PND) compared with placebo. PubMed, Embase, PsycINFO, MEDLINE, Cochrane Library, and CINAHL were searched from inception up to November 2019. The reference lists of relevant review articles and included studies were also reviewed. Randomized placebo-controlled trials examining the efficacy and safety of omega-3 FA monotherapy in perinatal women with depressive symptoms were included. Pooled standard mean differences (SMD) were calculated and random-effects models were adopted for all analyses. Subgroups analyses and meta-regression were performed to quantify characteristics of the subjects and trials influencing the omega-3 response. In addition, meta-regression was conducted to identify the source of heterogeneity. The study protocol was registered at PROSPERO, CRD42020159542. Eight eligible randomized placebo-controlled trials were included involving 638 participants. There was a significant effect of omega-3 FA on perinatal depression. Omega-3 with higher ratio of EPA/DHA (≥1.5) had significant efficacy both in mild-to-moderate pregnant and postpartum depression with low incidence of side effects. Among the included trials reporting adverse effects, there was no significant difference in incidence of gastrointestinal and neurologic events between the omega-3 and placebo groups. There was no evidence of publication bias. Our findings suggested that omega-3 FA significantly improved depressive symptoms in perinatal women regardless of pregnant or postpartum and well-tolerated. Furthermore, the omega-3 response was linked to higher EPA proportion in omega-3 formula and mild- to-moderate depression.
机译：作为营养素的欧米茄-3脂肪酸（FA）已被证明在主要抑郁症（MDD）中有效，但是，围产期抑郁症（PND）的单药治疗结果仍不清楚。与安慰剂相比，检查欧米茄-3脂肪酸（FA）单药治疗（PND）的疗效和安全性。从2009年11月开始搜查了PubMed，Embase，Psycinfo，Medline，Cochrane图书馆和Cinahl。还审查了相关审查文章的参考列表并包括研究。包括随机安慰剂对照试验检查欧米茄-3对围产期患有抑郁症状的围产期妇女的疗效和安全性。汇总标准平均差异（SMD）是计算的，并采用随机效应模型进行所有分析。进行亚组分析和荟萃回归，以量化影响ω-3反应的受试者和试验的特征。此外，进行了荟萃回归以识别异质性源。研究方案在Prospero，CRD42020159542注册。八个合格的随机安慰剂对照试验包括638名参与者。 Omega-3 Fa在围产期抑郁症有显着影响。 EPA / DHA（≥1.5）较高比例的ω-3在轻度至中度孕妇和产后抑郁症中具有显着的疗效，副作用低发生副作用。在包括欧米茄3和安慰剂组之间的胃肠道和神经系统发生率没有显着差异。没有出版物偏见的证据。我们的研究结果表明，无论怀孕还是产后，欧米茄-3 FA如何显着改善围产期患者的抑郁症状。此外，OMEGA-3反应与ω-3配方和温和至中等抑郁症的更高的EPA比例相关。

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