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首页> 外文期刊>Hematology >Prevalence and clinical significances of red cell alloimmunization and red cell bound immunoglobulin G in polytransfused patients with thalassemias
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Prevalence and clinical significances of red cell alloimmunization and red cell bound immunoglobulin G in polytransfused patients with thalassemias

机译：红细胞同种异体和红细胞结合免疫球蛋白G在多元化患者中红细胞含有红细胞结合免疫球蛋白G的患病率及临床意义

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The study was to determine the prevalence and clinical significances of red blood cell (RBC)-bound IgG as detected by flow cytometry in polytransfused patients with thalassemias.Relationship of the presence of RBC-bound IgG with RBC alloimmunization was also evaluated.This study included 59 polytransfused patients with β-thalassemia disease. We studied thefrequency of RBC autoantibodies and alloimmunization. Direct Coombs test and flowcytometry were performed to detect the presence of RBC autoantibodies while RBCalloantibodies were detected by antibody screening and identification assays.Eight (13.6%) and 34 (57.6%) patients were found a positive direct Coombs test and flowcytometry, respectively. Twenty (33.9%) patients developed RBC alloantibodies. The fourmost frequent RBC alloantibodies were anti-E (55%), anti-Mia (40%), anti-Di(a) (25%) and antic(15%), respectively. There was no significant difference in the presence of RBC-bound IgGbetween polytransfused with thalassemia patients who developed RBC alloimmunization (13of 20; 65%) and those without RBC alloantibodies (21 of 39; 53.8%), p = 0.412. Splenectomyand increased transfusion requirement were significantly associated with the presence ofRBC-bound IgG but not with RBC alloantibody formation.The overall frequency of RBC alloantibody formation in polytransfused patients withthalassemias was 33.9%. The most common RBC alloantibody was anti-E. RBC autoantibodyformation was more frequently detected by flow cytometry (57.6%) than by direct Coombstest (13.6%). Splenectomy was significantly associated with the development of autoreactiveRBC-bound IgG antibodies in the polytransfused patients with thalassemias. The presence ofthe anti-RBC autoantibodies may cause an increase of transfusion requirement.
机译：该研究是确定红细胞（RBC）-Bound IgG的患病率和临床意义，如通过半血清腺的多碎片患者的流式细胞术检测到。还评估了RBC AlloIMMunization的RBC结合IgG的存在。该研究包括在内59β-地中海贫血疾病的多血糖患者。我们研究了RBC自身抗体和同种异体的频繁。进行直接组织试验和流式细胞术以检测RBC自身抗体的存在，而通过抗体筛选和鉴定测定检测RBCAlloAlibodies.eight（13.6％）和34（57.6％）患者分别发现阳性直接组织试验和流式细胞率。二十（33.9％）患者开发了RBC Alloantibodies。最频繁的RBC Alloantibodibodibodies分别是抗E（55％），抗MIA（40％），抗二（a）（25％）和抗抗杀虫（15％）。与血清血症患者的RBC结合的Igbetweeen的存在没有显着差异，与其开发RBC AlloImmunization（13.0; 65％）和没有RBC AlloAlibodies的患者（21个，共39％; 53.8％），p = 0.412。脾乳粥样菌和增加的输血要求与RBC结合的IgG的存在显着相关，但不具有RBC Alloantibody Mablation的存在性。聚转盐患者中RBC Alloantibody形成的总频率为33.9％。最常见的RBC Alloantibody是抗E.通过流式细胞术（57.6％）比通过直接共体（13.6％）更频繁地检测RBC自身抗体。脾脏切除术与在多元血症患者中的自身反应性BC结合的IgG抗体显着相关。抗RBC自身抗体的存在可能导致输血要求增加。

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