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首页> 外文期刊>Dental Materials Journal >Effect of apigenin on surface-associated characteristics and adherence of Streptococcus mutans
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Effect of apigenin on surface-associated characteristics and adherence of Streptococcus mutans

机译：Apigenin对肝细胞异常的表面相关特征及粘附性的影响

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摘要

Apigenin is a type of flavonols that exhibits anti-caries properties. Bacterial adherence is the initial step in the forming of a stable biofilm that leads to caries. Bacterial adherence is affected by surface characteristics, including hydrophobicity and bacterial aggregation. However, the effect of apigenin on surface characteristics of cariogenic bacteria has not been reported. We aimed to examine the effects of apigenin on adherence and biofilm formation of Streptococcus mutans UA159. Hydrophobicity and bacterial aggregation, pac and gbpC gene expressions, and cytotoxicity on human dental pulp cells were also determined. Apigenin significantly inhibited the adherence and biofilm formation of S. mutans . Hydrophobicity decreased, whereas the aggregation rate was significantly increased compared with the control. Apigenin significantly suppressed pac and gbpC gene expressions. Apigenin exhibited acceptable biocompatibility on hDPCs. Thus, apigeinin may affect adherence and biofilm formation by altering the surface properties of S. mutans without obvious adverse effect on hDPCs.
机译：Apigenin是一种表现出抗龋性质的黄酮醇。细菌粘附是形成稳定的生物膜的初步步骤，其导致龋齿。细菌粘附受表面特征的影响，包括疏水性和细菌聚集。然而，尚未报道雌烯素对致癌细菌的表面特征的影响。我们的旨在检测Apigenin对粘附性和生物膜形成的粘附和生物膜形成的影响，Mutlococccus mutans UA159。还测定了疏水性和细菌聚集， PAC和 GBPC基因表达和人牙髓细胞上的细胞毒性。 Apigenin显着抑制了粘附和生物膜形成的粘附和生物膜。 mutans。疏水性降低，而与对照相比，聚集率明显增加。 Apigenin显着抑制 Pac和 GBPC基因表达。 Apigenin在HDPC上表现出可接受的生物相容性。因此，Apigeinin可以通过改变 S的表面性质来影响粘附和生物膜形成。对HDPC的明显不良反应。

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