Synthesis of 5, 5a??-methylenebis (benzofuran-5,2-diyl))bis(phenylmethanone) and its phenylhydrazonoe, benzenesulfonate derivatives and their anti-inflammatory activity

Bhookya Shankar; Pochampally Jalapathi; Sunitha Vianala; Karunakar Rao Kudle

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Synthesis of 5, 5a??-methylenebis (benzofuran-5,2-diyl))bis(phenylmethanone) and its phenylhydrazonoe, benzenesulfonate derivatives and their anti-inflammatory activity

机译：合成5,5A ?? - 亚甲基（Benzofuran-5,2-二基）的双（苯甲基甲酰胺）及其苯基羟基芳基，苯磺酸盐衍生物及其抗炎活性

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Some novel anti-inflammatory entities derived from 5, 5’-methylenebis (benzofuran-5,2-diyl))bis(phenylmethanone, the structures of these compounds were elucidated by FTIR, 1H-NMR, 13C-NMR and Mass spectral analysis. Furthermore, all the compounds were evaluated for their activity using the carrageenan-induced rat paw edema method. Among the synthesized compounds, 4b, 4d, 4f, 6a and 6c showed significant (p 0.01) reduction of rat paw edema volume, 4b & 6c showed the maximum anti-inflammatory activity after 24 h from the admin of the carrageenan compared to the standard drug, Ibuprofen.

机译：一些新的抗炎实体来自5,5'-亚甲基比（苯并呋喃-5,2-二基））双（苯甲基甲基，这些化合物的结构通过FTIR，1H-NMR，13C-NMR和质谱分析阐明。此外，通过角叉菜胶诱导的大鼠爪水肿方法评价所有化合物的所有化合物。在合成化合物，4b，4d，4f，6a和6c中，大鼠爪子水肿体积的显着（p <0.01）减少，4b＆图6C与标准药物，布洛芬的标准药物相比，从角叉菜胶的施用后24小时后显示出最大的抗炎活性。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2016年第7期|共8页
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Bhookya Shankar; Pochampally Jalapathi; Sunitha Vianala; Karunakar Rao Kudle;
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Synthesis of 5, 5a??-methylenebis (benzofuran-5,2-diyl))bis(phenylmethanone) and its phenylhydrazonoe, benzenesulfonate derivatives and their anti-inflammatory activity

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