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首页> 外文期刊>Drug Design, Development and Therapy >Protective Effects of Rocuronium Bromide on Ischemia-Reperfusion Injury in Skeletal Muscle Induced by Tourniquet in Patients Undergoing Elective Unilateral Total Knee Arthroplasty: A Prospective, Double Blind, Randomized, Controlled Study
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Protective Effects of Rocuronium Bromide on Ischemia-Reperfusion Injury in Skeletal Muscle Induced by Tourniquet in Patients Undergoing Elective Unilateral Total Knee Arthroplasty: A Prospective, Double Blind, Randomized, Controlled Study

机译：罗酮溴化物对止血带骨骼肌缺血再灌注损伤的保护作用在接受选修单侧全膝关节置换术患者中的脑肌轴承术：一种前瞻性，双盲，随机，对照研究

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Purpose: To investigate the effects of different doses of rocuronium on ischemia-reperfusion injury in skeletal muscle induced by tourniquet in patients undergoing elective unilateral total knee arthroplasty. Patients and Methods: A total of 90 patients undergoing elective unilateral knee arthroplasty under general anesthesia combined with femoral nerve block were randomly divided into 3 groups: normal saline group (group S), rocuronium 0.6 mg/kg group (group L), and rocuronium 1.2 mg/kg group (group H). The primary outcome was the expression of dystrophin in skeletal muscle at 60 min after ischemia. Secondary outcomes included the concentration of malondialdehyde (MDA) and neuronal nitric oxide synthase (nNOS) in blood at 5 min and 30 min after reperfusion. In addition, thigh girth at 24 h and 48 h after operation, the leaving bed time, the incidence of tourniquet-related hypertension and short-term (3 days after operation) complications (nausea and vomiting, swelling, blister, wound infection) and long-term (3 months after operation) complications (joint instability, stiffness, nerve paralysis, pain) were recorded. Main Results: The expression of dystrophin in the rocuronium group was higher than that in group S after ischemia ( P 0.05). The concentration of MDA in the rocuronium 1.2 mg/kg group was lower at 30 min after reperfusion ( P 0.05). The change of thigh girth was the smallest in the rocuronium 1.2 mg/kg group after operation ( P 0.05). The leaving bed time was significantly earlier after operation in the rocuronium group than that in group S ( P 0.05). Conclusion: Rocuronium can protect skeletal muscle from ischemia-reperfusion injury induced by tourniquet. The mechanism may be related to the fact that rocuronium can reduce the loss of dystrophin in skeletal muscle and have the effects of anti-oxidation and anti-stress. Trial Registration: The study was registered at http://www.chictr.org.cn (ChiCTR1800019221, registered on 2018– 10-31).
机译：目的：探讨不同剂量罗酮对脑腹肌缺血再灌注损伤的影响，脑腹肌肉肌膝关节置换术患者。患者和方法：在全身麻醉下，共有90例接受选修单侧膝关节置换术的患者随机分为3组：正常盐碱（群），罗潴鎓0.6mg / kg组（L）和罗克尼铵1.2 mg / kg组（群体H组）。主要结果是在缺血后60分钟在骨骼肌中表达肌肌的表达。二次结果包括在再灌注后5分钟和30分钟的血液中丙醛（MDA）和神经元一氧化氮合酶（NNOS）的浓度。此外，术后大腿周长和48小时，离开床时间，止血带相关的高血压发病率和短期（手术后3天）并发症（恶心和呕吐，肿胀，泡沫，伤口感染）和记录了长期（手术后3个月）并发症（关节不稳定性，僵硬，神经麻痹，疼痛）。主要结果：在缺血后罗孔基团中营养不良蛋白的表达高（P <0.05）。再灌注后30分钟后罗孔1.2mg / kg基团MDA的浓度（P 0.05）。大腿周长的变化是rocuronium 1.2mg / kg组的最小术后（P <0.05）。在罗科尼鎓组的操作之后，去床时间显着早于群体（P <0.05）。结论：罗科酮可以保护止血带诱导缺血再灌注损伤的骨骼肌。该机制可能与罗孔鎓可以减少骨骼肌中营养不良蛋白损失的事实有关，并且具有抗氧化和抗应力的影响。审判登记：该研究在http://www.chictr.org.cn（Chictr1800019221，2018-10-31注册）。

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