• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drug Design, Development and Therapy >Effect of Intravenous Injection of Vitamin C on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Double-Blind, Randomized Trial
【24h】

Effect of Intravenous Injection of Vitamin C on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Double-Blind, Randomized Trial

机译：维生素C对心脏手术患者术后肺并发症的影响：双盲，随机试验

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: In this study, the effect of intravenous vitamin C during surgery on the incidence of postoperative pulmonary complications (PPCs) in patients undergoing cardiopulmonary bypass and cardiac surgery was observed, and its protective effect on the lungs was evaluated to provide a reference for clinical medication. Patients and Methods: Patients undergoing cardiac surgery under cardiopulmonary bypass (CPB) were selected. The patients were divided into group A and group C by random sequence. Patients in group A received intravenous vitamin C 1 g 10 minutes after induction of anesthesia, 10 minutes before cardiac reanimation and at the moment of sternal closure. Patients in group C were intravenously injected with the same volume of saline at the same time. The primary outcome was the postoperative pulmonary complication severity score. Other outcomes were the incidence of PPCs, awakening time, extubation time, length of ICU stay, length of hospital stay, adverse events, oxygenation index (PaO2/FiO2), alveolar arterial oxygen partial pressure difference (A-aDO2), dynamic lung compliance (Cd) and static lung compliance (Cs). Results: Seventy patients completed the study. Compared to group C, the postoperative pulmonary complication score [2(2– 3) vs 2(1– 2); P =0.009] and the incidence of postoperative pulmonary complications (32.43% vs 12.12%; P =0.043) were lower in group A. There were no significant differences in awakening time, extubation time, length of ICU stay, length of hospital stay, adverse events, PaO2/FiO2, A-aDO2 0.05). Conclusion: In summary, this small randomized trial including low-risk cardiac surgery patients shows that intravenous vitamin C may safely be administered and may be helpful to prevent PPCs after cardiac surgery.
机译：目的：在本研究中，观察到静脉内维生素C对术后肺并发症发病率（PPC）的疗效观察到进行心肺旁路和心脏手术的术后，评价对肺部的保护作用，为临床提供参考药物。患者和方法：选择患者在心肺旁路（CPB）下进行心脏手术的患者。通过随机序列将患者分成A组和C组。患者在诱导麻醉后10分钟接受静脉内维生素C1g 10分钟，在心脏恢复前10分钟，在胸骨闭合时。 C组患者同时静脉内注射相同体积的盐水。主要结果是术后肺并发症严重性得分。其他结果是PPC的发病率，唤醒时间，拔管时间，ICU的长度，住院时间长度，不良事件，氧合指数（PAO2 / EIO2），肺泡动脉氧分压差（A-ADO2），动态肺顺应性（CD）和静态肺顺应性（CS）。结果：七十名患者完成了研究。与C组相比，术后肺并发症得分[2（2-3）Vs 2（1-2）; P = 0.009]和术后肺并发症的发生率（32.43％vs12.12％; p = 0.043）较低，唤醒时间没有显着差异，拔管时间，ICU的长度，住院时间长度，不良事件，PAO2 / FiO2，A-ADO2 0.05）。结论：总之，这种小型随机试验包括低风险心脏手术患者表明，可以安全地施用静脉内维生素C，可能有助于防止心脏手术后PPCs。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号