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Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin

机译：姜黄素可以防止放疗诱导的皮肤氧化损伤

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Objective: Side-effects to normal tissues reduce the therapeutic window of radiotherapy. During radiotherapy, the skin is inevitably exposed to doses of ionizing radiation, leading to varying degrees of skin damage. Natural antioxidants have been explored for their radioprotective potentials. Thus, the present study aimed to investigate the protective effect of curcumin against radiotherapy-induced oxidative damage to the skin. Methods: Forty rats were divided into four groups as follows: vehicle control (without irradiation or drug treatment), treatment with 150 mg/kg curcumin, 10 Gy single dose irradiation only, and 150 mg/kg curcumin plus 10 Gy radiation (RC). In the treatment groups, each rat was treated orally with 150 mg/kg curcumin 1 day before irradiation to 3 consecutive days after irradiation. Weeks 1, 2, or 4 after irradiation, all rats were sacrificed and their skin tissues collected and frozen at ? 80°C for the determination of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity in skin tissues. Results: Radiotherapy-induced oxidative injury to the skin was evidenced by elevated MDA levels as well as depleted CAT, SOD, and GSH-Px activities. However, the administration of curcumin before and after irradiation prevented radiotherapy-induced oxidative damage by significantly elevating the activities of antioxidant enzymes. Conclusion: From the findings of the present study, curcumin showed potential for protection against radiotherapy-induced oxidative injury to the skin. However, future studies are required to evaluate its clinical efficacy.
机译：目的：对正常组织的副作用减少放射治疗的治疗窗。在放射疗法期间，皮肤不可避免地暴露于电离辐射的剂量，导致不同程度的皮肤损伤。已经探索了天然抗氧化剂的辐射防护潜​​力。因此，本研究旨在探讨姜黄素对皮肤放射疗法诱导的氧化损伤的保护作用。方法：将40只大鼠分为四组：车辆控制（无照射或药物处理），用150mg / kg姜黄素治疗，仅为10 Gy单剂量照射，150mg / kg姜黄素加10GY辐射（RC） 。在治疗组中，每次大鼠用150mg / kg姜黄素治疗1天，然后在照射后连续3天。辐照后的数周1,2或4，处死所有大鼠，并收集其皮肤组织并冷冻？ 80℃用于测定皮肤组织中的丙二醛（MDA），过氧化氢酶（猫），超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-PX）活性的谷氨酸酶。结果：通过升高的MDA水平以及耗尽的猫，SOD和GSH-PX活动，证明了对皮肤的氧化损伤的放射疗法诱导的氧化损伤。然而，通过显着升高抗氧化酶的活性，在照射前后施用姜黄素诱导放射疗法诱导的氧化损伤。结论：从本研究的结果，姜黄素显示出防辐射诱导的皮肤氧化损伤的潜力。然而，未来的研究是评估其临床疗效的研究。

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