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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Expression of microRNAs-106b in nonsmall cell lung cancer
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Expression of microRNAs-106b in nonsmall cell lung cancer

机译：MicroRNA-106B在非球细胞肺癌中的表达

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Aim: To explore the expression of microRNA-106b (miRNA-106b) in nonsmall cell lung cancer (NSCLC). Settings and Design: miRNAs are short regulatory RNAs that negatively modulate gene expression at the posttranscriptional level, and are deeply involved in the pathogenesis of several types of cancer. miRNA-106b has been shown to play an oncogenic role in tumor progression. The expression of miRNA-106b is detected in this study. Subjects and Methods: Quantitative reverse transcription polymerase chain reaction and Northern blotting were used to detect the expression level of miRNA-106b in 200 NSCLC samples. Statistical Analysis Used: All statistical analyses were performed using SPSS 16.0 software. Results were statistically evaluated using the Kruskal–Wallis test and Mann–Whitney U-test. Survival curves were estimated by the Kaplan–Meier method and P Results: miRNA-106b expression is increased in NSCLC tissues. Statistical analysis showed that overexpression of miRNA-106b was strongly associated with lymph node metastasis, stage of tumor node metastasis classification, and poor prognosis. Moreover, there was a significant difference in the miRNA-106b expression levels between smoking and nonsmoking patients. Multivariate Cox regression analysis showed that miRNA-106b was an independent prognostic factor for NSCLC patients. Conclusions: These data suggest that aberrantly expressed miRNA-106b may contribute to the development of NSCLC.
机译：目的：探讨MicroRNA-106B（miRNA-106b）在非物质细胞肺癌（NSCLC）中的表达。设置和设计：miRNA是短暂的调节RNA，可在后术语水平下对基因表达进行负面调节，并且深入参与几种类型癌症的发病机制。 MiRNA-106B已被证明在肿瘤进展中发挥致癌作用。在该研究中检测miRNA-106b的表达。对象和方法：定量逆转录聚合酶链反应和Northern印迹用于检测200个NSCLC样品中miRNA-106b的表达水平。使用的统计分析：使用SPSS 16.0软件进行所有统计分析。结果使用Kruskal-Wallis测试和Mann-Whitney U-Test进行统计评估。 KAPLAN-MEIER方法估计生存曲线，P结果：在NSCLC组织中MiRNA-106B表达增加。统计学分析表明，MiRNA-106B的过表达与淋巴结转移，肿瘤节点转移分类阶段强烈相关，预后差。此外，吸烟和非莫斯莫治疗患者的miRNA-106B表达水平存在显着差异。多变量Cox回归分析表明，MiRNA-106B是NSCLC患者的独立预后因素。结论：这些数据表明，异常表达的miRNA-106B可能有助于NSCLC的发展。

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