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首页> 外文期刊>Journal of Clinical Medicine >Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features
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Quantitative Analysis of Somatostatin and Dopamine Receptors Gene Expression Levels in Non-functioning Pituitary Tumors and Association with Clinical and Molecular Aggressiveness Features

机译：生长抑素和多巴胺受体基因表达水平的定量分析与脑垂体肿瘤的非功能性脑肿瘤和临床和分子侵袭性特征

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The primary treatment for non-functioning pituitary tumors (NFPTs) is surgery, but it is often unsuccessful. Previous studies have reported that NFPTs express receptors for somatostatin (SST 1-5 ) and dopamine (DRDs) providing a rationale for the use of dopamine agonists and somatostatin analogues. Here, we systematically assessed SST 1-5 and DRDs expression by real-time quantitative PCR (RT-qPCR) in a large group of patients with NFPTs ( n = 113) and analyzed their potential association with clinical and molecular aggressiveness features. SST 1-5 expression was also evaluated by immunohistochemistry. SST 3 was the predominant SST subtype detected, followed by SST 2 , SST 5 , and SST 1 . DRD2 was the dominant DRD subtype, followed by DRD4, DRD5, and DRD1. A substantial proportion of NFPTs displayed marked expression of SST 2 and SST 5 . No major association between SST s and DRDs expression and clinical and molecular aggressiveness features was observed in NFPTs.
机译：非功能性垂体肿瘤（NFPTS）的主要治疗是手术，但通常不成功。以前的研究报道，NFPTS表达SOMatostatin（SST 1-5）和多巴胺（DRDS）的表达受体提供了用于使用多巴胺激动剂和生长抑素类似物的理由。在这里，我们通过实时定量PCR（RT-QPCR）系统地评估SST 1-5和DRDS表达，并在一大群NFPTS（n = 113）患者中，并分析它们与临床和分子侵袭性的潜在关联。 SST 1-5表达也通过免疫组织化学评估。 SST 3是检测到的主要SST亚型，其次是SST 2，SST 5和SST 1。 DRD2是主导DRD子类型，其次是DRD4，DRD5和DRD1。大量比例的NFPT显示SST 2和SST 5的显着表达。在NFPT中没有观察到SST S和DRDS表达和临床和分子侵略性特征之间的主要关联。

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