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首页> 外文期刊>Journal of Clinical Medicine >Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI
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Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI

机译：衰老与Peri-Sinus淋巴空间体积呈正相关：使用3T黑血液MRI进行评估

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Objectives: Aging is a major risk factor for many neurological disorders and is associated with dural lymphatic dysfunction. We sought to evaluate the association of aging with the volume of the peri-sinus lymphatic space using contrast-enhanced 3T T1-weighted black-blood magnetic resonance imaging (MRI). Methods: In this retrospective study, 165 presumed neurologically normal subjects underwent brain MRIs for cancer staging between April and November 2018. The parasagittal peri-sinus lymphatic space was evaluated using contrast-enhanced 3D T1-weighted black-blood MRIs, and volumes were measured with semiautomatic method. We compared the volumes of normalized peri-sinus lymphatic spaces between the elderly (≥65 years, n = 72) and non-elderly ( n = 93) groups and performed multivariate logistic regression analyses to assess if aging is independently associated with the volume of normalized peri-sinus lymphatic spaces. Results: The normalized peri-sinus lymphatic space volume was significantly higher in the elderly than in the non-elderly (mean, 3323 ± 758.7 mL vs. 2968.7 ± 764.3 mL, p = 0.047). After adjusting the intracranial volume, age age was the strongest factor independently associated with peri-sinus lymphatic space volume (β coefficient, 28.4 (5.7–51.2), p = 0.015) followed by male sex (β coefficient, 672.4 (113.5–1230.8), p = 0.019). Conclusions: We found that the peri-sinus dural lymphatic space volume was higher in the elderly group than in the non-elderly group, and the increased peri-sinus lymphatic space was independently associated with aging. These findings indicate that the peri-sinus lymphatic space may be related with the aging process and lymphatic system dysfunction as well.
机译：目的：老化是许多神经系统障碍的主要危险因素，并且与多云淋巴功能障碍有关。我们试图使用对比增强的3T T1加权黑血磁共振成像（MRI）来评估衰老的衰老与围鼻淋巴空间的体积。方法：在该回顾性研究中，165项假定的神经学正常受试者在2018年4月和11月期间接受了癌症分期的脑衰退。使用对比增强的3D T1加权的黑血病评估了促剖腹腺膜淋巴结，测量了体积具有半自动方法。比较了老年人（≥65岁，N = 72）和非老年人（n = 93）组之间的归一化围窦淋巴结的体积，并进行了多元逻辑回归分析，以评估老化是否与体积单独相关规范化的腹窦淋巴结。结果：老年人的正常化Peri-Sinus淋巴空间体积显着高于非老年人（平均值，3323±758.7ml与2968.7±764.3ml，P = 0.047）。调整颅内体积后，年龄是与Peri-Sinus淋巴空间体积（β系数，28.4（5.7-51.2），p = 0.015）和男性性别（β系数，672.4（113.5-1230.8）相关的最强因素。 ，p = 0.019）。结论：我们发现，老年群中的腹窦淋巴结均高于非老年群，并且增加的腹窦淋巴结空间与老化有关。这些发现表明，周窦淋巴结可能与老化过程和淋巴系统功能障碍有关。

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