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首页> 外文期刊>Journal of Clinical Medicine >A Retrospective Propensity Score Matched Analysis Reveals Superiority of Hypothermic Machine Perfusion over Static Cold Storage in Deceased Donor Kidney Transplantation
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A Retrospective Propensity Score Matched Analysis Reveals Superiority of Hypothermic Machine Perfusion over Static Cold Storage in Deceased Donor Kidney Transplantation

机译：回顾性倾向得分匹配分析揭示了死亡肾移植中静电储存的低温机灌注的优越性

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Hypothermic machine perfusion (HMP) has been introduced as an alternative to static cold storage (SCS) in kidney transplantation, but its true benefit in the clinical routine remains incompletely understood. The aim of this study was to assess the effect of HMP vs. SCS in kidney transplantation. All kidney transplants performed between 08/2015 and 12/2019 ( n = 347) were propensity score (PS) matched for cold ischemia time (CIT), extended criteria donor (ECD), gender mismatch, cytomegalovirus (CMV) mismatch, re-transplantation and Eurotransplant (ET) senior program. A total of 103 HMP and 103 SCS instances fitted the matching criteria. Prior to PS matching, the CIT was longer in the HMP group (17.5 h vs. 13.3 h; p 0.001), while the delayed graft function (DGF) rates were 29.8% and 32.3% in HMP and SCS, respectively. In the PS matched groups, the DGF rate was 64.1% in SCS vs. 31.1% following HMP: equivalent to a 51.5% reduction of the DGF rate (OR 0.485, 95% CI 0.318–0.740). DGF was associated with decreased 1- and 3-year graft survival (100% and 96.3% vs. 90.8% and 86.7%, p = 0.001 and p = 0.008) or a 4.1-fold increased risk of graft failure (HR = 4.108; 95% CI: 1.336–12.631; p = 0.014). HMP significantly reduces DGF in kidney transplantation. DGF remains a strong predictor of graft survival.
机译：已经引入低温机灌注（HMP）作为肾移植静态冷储存（SCS）的替代方案，但其在临床常规中的真正益处仍然不完全理解。本研究的目的是评估HMP与SCS在肾移植中的影响。在08/2015和12/2019（n = 347）之间进行的所有肾移植均为倾向，对冷缺血时间（CIT），扩展标准供体（ECD），性别错配，细胞瘤病毒（CMV）失配，重新匹配移植和Eurotransplant（et）高级计划。共有103个HMP和103个SCS实例拟合了匹配标准。在PS匹配之前，CIT在HMP组中更长（17.5小时与13.3小时; P <0.001），而延迟接枝函数（DGF）率分别为HMP和SCS的29.8％和32.3％。在PS匹配的基团中，在HMP下，DGF率为31.1％的DGF率为31.1％：相当于降低DGF率的51.5％（或0.485,95％CI 0.318-0.740）。 DGF与下降1-至3年的移植物存活（100％和96.3％，50.8％和86.7％，P = 0.001和P = 0.008）或接枝衰竭的风险增加4.1倍（HR = 4.108; 95％CI：1.336-12.631; p = 0.014）。 HMP在肾移植中显着降低了DGF。 DGF仍然是移植物生存期的强烈预测因子。

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