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首页> 外文期刊>Transplant international : >Machine perfusion following static cold storage preservation in kidney transplantation: Donor-matched pair analysis of the prognostic impact of longer pump time
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Machine perfusion following static cold storage preservation in kidney transplantation: Donor-matched pair analysis of the prognostic impact of longer pump time

机译：肾脏移植中静态冷库保存后的机器灌注：供体配对分析延长泵送时间对预后的影响

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The impact of machine perfusion (MP) time on kidney transplant outcome is mixed in previous studies using multivariable analyses. In an analysis of 66 pairs of donor-matched adult, first transplant recipients (N = 132) with identical donor characteristics except for pump time, tests of association of shorter versus longer pump time (first versus second kidney removed) by delayed graft function(DGF), slow graft function(SGF), and biopsy proven acute rejection(BPAR) were performed using McNemar's test. Freedom-from-BPAR, graft and patient survival, and renal function were also compared. Mean ± SD pump times for paired recipients with first and second kidneys were 22.7 ± 7.3 h and 31.2 ± 7.9 h, respectively (mean difference: 8.5 ± 4.5 h, P <.000001). There was no significant impact of pump time on DGF or SGF, with discordant pairs favoring less SGF with longer pump time (N.S.). The incidence of BPAR during the first 12 months post-transplant yielded a borderline difference favoring longer pump time (P =.09), and freedom-from-BPAR during the first 12 months was significantly more favorable for longer pump times (95% vs. 84%, P = 0.04). No differences were observed in graft and patient survival, and renal function. While offering significantly favorable protection from BPAR, this analysis of donor-matched recipient pairs corroborates longer MP (pump) times having no unfavorable effect on other clinical outcomes.
机译：在以前的研究中，使用多变量分析将机器灌注（MP）时间对肾脏移植结果的影响混合在一起。在对66对供体匹配的成年，初次移植受者（N = 132）的供体特征相同的分析中，除了抽血时间不同外，通过延迟移植功能对抽血时间短与抽血时间长（第一肾与第二肾摘除）的关联性进行了测试（使用McNemar检验进行了DGF），缓慢移植功能（SGF）和活检证实的急性排斥反应（BPAR）。还比较了无BPAR，移植和患者生存率以及肾功能。配对的第一肾脏和第二肾脏接受者的平均±SD泵送时间分别为22.7±7.3 h和31.2±7.9 h（平均差：8.5±4.5 h，P <.000001）。抽气时间对DGF或SGF没有显着影响，不和谐对倾向于较少的SGF和较长的抽气时间（N.S.）。移植后前12个月的BPAR发生率产生了临界差异，有利于延长泵浦时间（P = .09），而最初12个月的BPAR自由度对于更长的泵浦时间更为有利（95％vs 84％，P = 0.04）。在移植物和患者的存活率以及肾功能方面未观察到差异。在提供对BPAR的显着有利保护的同时，这种对供体匹配的受体对的分析证实了更长的MP（泵）时间，对其他临床结局没有不利影响。

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