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首页> 外文期刊>Journal of Clinical Medicine >Association of Regional Bone Synthetic Activities of Vertebral Corners and Vertebral Bodies Quantified Using 18 F-Fluoride Positron Emission Tomography with Bone Mineral Density on Dual Energy X-ray Absorptiometry in Patients with Ankylosing Spondylitis
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Association of Regional Bone Synthetic Activities of Vertebral Corners and Vertebral Bodies Quantified Using 18 F-Fluoride Positron Emission Tomography with Bone Mineral Density on Dual Energy X-ray Absorptiometry in Patients with Ankylosing Spondylitis

机译：椎体角和椎体的区域骨合成活性与骨密度与骨密度骨密度骨密度定量的椎体和椎体的结合，脊髓脊柱胸腺炎患者双能X射线吸收测定法

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摘要

We investigated whether the bone-synthetic activities of vertebral bodies or vertebral corners quantified using 18 F-fluoride positron emission tomography (PET) was associated with bone mineral density (BMD) at the corresponding lumbar vertebrae in ankylosing spondylitis (AS) at each vertebra level. We analyzed 48 lumbar vertebrae in 12 AS patients who underwent 18 F-fluoride PET and dual energy X-ray absorptiometry (DXA). The mean standardized uptake values (SUVmean) of the vertebral body and corners from L1 to L4 were measured using the spatially separated region of interest (ROI). The L1–L4 BMDs were calculated based on the DXA (“conventional BMD”). The BMD of the internal vertebral bodies was measured by manually drawing ROIs to represent the trabecular BMD (“alternative BMD”). After adjusting the within-patient correlation, the 18 F-fluoride SUVmean of the vertebral corners but not that of vertebral bodies was significantly related with the conventional BMD of the vertebra. Otherwise, the 18 F-fluoride uptake of both the vertebral and vertebral bodies was significantly related with the alternative BMD. The bone-synthetic activities of the vertebral corners may be more closely related with BMD than those of the vertebral bodies, suggesting that the effects of regional bone metabolism at the vertebral corners and bodies on BMD differ in AS.
机译：我们研究了使用18 F-氟化物正电子发射断层扫描（PET）定量的椎体或椎体的骨合成活性是否与在每个椎骨（AS）的相应腰椎上的骨矿物密度（BMD）相关联。我们在12名患者中分析了48名腰椎，作为患者18个F-氟化物PET和双能X射线吸收测定法（DXA）。使用空间分离的目的区域（ROI）测量来自L1至L4的椎体和角落的平均标准化摄取值（SUVmean）。基于DXA（“常规BMD”）计算L1-L4 BMD。通过手动抽取rOI来测量内部椎体的BMD以代表小梁BMD（“替代BMD”）。在调整患者内部相关性之后，椎体的18个F-氟化物Suvmean但不是椎体的偏移与椎体的常规BMD显着相关。否则，椎体和椎体的18氟化物摄取与替代BMD显着相关。椎体骨骼的骨合成活性与BMD的骨合成活性比椎体的合成活性更密切，这表明区域骨代谢在BMD上的椎体弯曲物和体内的影响有所不同。

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