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首页> 外文期刊>Journal of Clinical Medicine >Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome
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Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome

机译：单核细胞化学蛋白-1是急性冠状动脉综合征患者冠状动脉畸形的独立预测因子

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Our purpose was to assess a possible association of inflammatory, lipid and mineral metabolism biomarkers with coronary artery ectasia (CAE) and to determine a possible association of this with acute atherotrombotic events (AAT). We studied 270 patients who underwent coronary angiography during an acute coronary syndrome 6 months before. Plasma levels of several biomarkers were assessed, and patients were followed during a median of 5.35 (3.88–6.65) years. Two interventional cardiologists reviewed the coronary angiograms, diagnosing CAE according to previously published criteria in 23 patients (8.5%). Multivariate binary logistic regression analysis was used to search for independent predictors of CAE. Multivariate analysis revealed that, aside from gender and a diagnosis of dyslipidemia, only monocyte chemoattractant protein-1 (MCP-1) (OR = 2.25, 95%CI = (1.35–3.76) for each increase of 100 pg/mL, p = 0.001) was independent predictor of CAE, whereas mineral metabolism markers or proprotein convertase subtilisin/kexin type 9 were not. Moreover, CAE was a strong predictor of AAT during follow-up after adjustment for other clinically relevant variables (HR = 2.67, 95%CI = (1.22–5.82), p = 0.013). This is the first report showing that MCP-1 is an independent predictor of CAE, suggesting that CAE and coronary artery disease may share pathogenic mechanisms. Furthermore, CAE was associated with an increased incidence of AAT.
机译：我们的目的是评估具有冠状动脉斑态（CAE）的炎症，脂质和矿物代谢生物标志物的可能协会，并确定与急性躯体粥样硬化事件（AAT）的可能结合。我们研究了270名患者在急性冠状动脉综合征术前6个月前接受冠状动脉造影。评估几种生物标志物的血浆水平，患者在5.35（3.88-65.65）年中间。两位介入的心脏病学家审查了冠状动脉血管造影，根据先前公布的23名患者的标准诊断CAE（8.5％）。多变量二进制物流回归分析用于搜索CAE的独立预测因子。多变量分析表明，除了性别和血脂血症的诊断之外，只有单核细胞化学蛋白-1（MCP-1）（或= 2.25,95％CI =（1.35-3.76），每增加100pg / ml，p = 0.001）是CAE的独立预测因子，而矿物代谢标志物或先前素转化酶枯草杆菌蛋白酶/ kexin型4是不存在的。此外，CAE在调整其他临床相关变量后的随访期间是AAT的强预测因子（HR = 2.67,95％CI =（1.22-5.82），P = 0.013）。这是第一个报告，显示MCP-1是CAE的独立预测因子，表明CAE和冠状动脉疾病可能共享致病机制。此外，CAE与AAT的发病率增加有关。

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