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首页> 外文期刊>Journal of Clinical Medicine >Effect of Botulinum Toxin A on Scar Healing after Thyroidectomy: A Prospective Double-blind Randomized Controlled Trial
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Effect of Botulinum Toxin A on Scar Healing after Thyroidectomy: A Prospective Double-blind Randomized Controlled Trial

机译：肉毒杆菌毒素A对甲状腺切除术后瘢痕愈合的影响：一种前瞻性双盲随机对照试验

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摘要

The persistence of neck scarring is a common concern among patients undergoing thyroidectomy. Botulinum toxin A (BTA (Botox)) has been shown to suppress scar enlargement at the incision site. The objective of this study was to evaluate the effect of intraoperative Botox administration on neck scarring after thyroidectomy. A prospective double-blind randomized clinical trial was performed in patients undergoing conventional thyroidectomy. Forty patients were randomly allocated to a Botox or a control group (both, n = 20). The wound was closed after injection into the platysma muscle of 50 U of Botox diluted in 1 mL of normal saline or 1 mL of saline alone. Skin scars were assessed using the modified Stony Brook Scar Evaluation Scale (SBSES) and Manchester Scar Scale (MSS) at 1, 12, and 24 weeks postoperatively. The SBSES and MSS scores of the Botox group were significantly better than those of the control group ( p = 0.034 and p = 0.039). At 24 weeks postoperatively, the SBSES and MSS scores were significantly better in the Botox group ( p = 0.006 and p = 0.030). BTA injected into the incision site can suppress postoperative scar formation and thereby improve the cosmetic outcome.
机译：颈部疤痕的持久性是接受甲状腺切除术的患者的共同关心。已显示肉毒杆菌毒素A（BTA（BOTOX））抑制切口部位的瘢痕增大。本研究的目的是评估甲状腺切除术后术中肉毒杆菌毒素给药对颈部瘢痕的影响。在经过常规甲状腺切除术的患者进行预期双盲随机临床试验。将四十名患者随机分配给肉毒杆菌或对照组（两者，n = 20）。在注射到50u U单独稀释1ml甘油蛋棒或单独1ml盐水中的肉毒杆菌的血液肌中闭合伤口。使用修改的石质粗鲁瘢痕评估标度（SBSES）和曼彻斯特疤痕尺度（MSS）在术后1,12和24周评估皮肤瘢痕。肉毒杆菌组的SBSES和MSS分数明显优于对照组（P = 0.034和P = 0.039）。在术后24周，肉毒杆菌基团SBSES和MSS分数明显更好（P = 0.006和P = 0.030）。注射到切口部位的BTA可以抑制术后瘢痕形成，从而改善化妆品结果。

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