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首页> 外文期刊>Journal of Clinical Medicine >Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma
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Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma

机译：验证低钠血症作为多河尿路上皮癌中的预后预测因子

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Hyponatremia has been shown to be associated with prognosis in various cancers, but its role in upper tract urothelial carcinoma (UTUC) is largely unidentified. We created an international multiregional cohort of UTUC, consisting of 524 and 213 patients from Taiwan and the U.S., to validate the significance of hyponatremia. Clinicopathologic characteristics were compared according to the presence of hyponatremia. Univariate and multivariate Cox regression models were used to investigate the association of hyponatremia with disease progression and survival. The impact of hyponatremia in patients from distinct regions was also analyzed. Hyponatremia was found in 143 (19.4%) patients. Hyponatremic patients had significantly worse Eastern Cooperative Oncology Group (ECOG) performance status ( p = 0.00001) and higher pT stage ( p = 0.002). In multivariate analysis, hyponatremia was an independent prognostic factor for progression (HR 1.585, 95% CI 1.115–2.253, p = 0.010), cancer-specific death (HR 2.225, 95% CI 1.457–3.397, p = 0.0002), and overall mortality (HR 1.819, 95% CI 1.299–2.545, p = 0.0005). Kaplan–Meier analysis showed the consistent adverse effect of hyponatremia on all outcomes in patients from Taiwan and the U.S. (all p 0.05). Hyponatremia is commonly accessible and can serve as a negative marker for both the general health condition and disease severity of UTUC patients. A similar implication of hyponatremia in progression and survival despite patients’ region of presentation suggests its general applicability across different ethnicities.
机译：低钠血症已被证明与各种癌症的预后有关，但其在上部道尿路上皮癌（UTUC）中的作用在很大程度上是未鉴定的。我们创建了一个由台湾和美国的524和213名患者组成的国际多次多次多律队列，验证了低钠血症的重要性。根据低钠血症的存在进行比较临床病理特征。单变量和多元COX回归模型用于研究低钠血症与疾病进展和生存的关联。还分析了不同地区患者的低钠血症的影响。低钠血症在143名（19.4％）患者中被发现。低管患者的东方合作肿瘤学群（ECOG）性能状态（P = 0.00001）和更高的PT阶段（P = 0.002）。在多变量分析中，低钠血症是进展的独立预后因素（HR 1.585,95％CI 1.115-2.253，P = 0.010），癌症特异性死亡（HR 2.225,95％CI 1.457-3.397，P = 0.0002），以及总体死亡率（HR 1.819,95％CI 1.299-2.545，P = 0.0005）。 Kaplan-Meier分析表明，低钠血症对台湾和美国患者所有结果的一致不良影响（所有P <0.05）。低钠血症是常见的，可以作为utuc患者的一般健康状况和疾病严重程度作为阴性标志物。尽管患者的展示地区，虽然患者的进展和生存率在进展和生存中的类似含义表明其在不同种族中的一般适用性。

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