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首页> 外文期刊>Journal of Clinical Medicine >Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study
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Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study

机译：Sugammadex对腹腔镜胃切除术后肺并发症的影响：回顾性队列研究

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The use of sugammadex can reduce post-operative residual neuromuscular blockade, which is known to increase the risk of post-operative respiratory events. However, its effect on post-operative pulmonary complications is not obvious. This study was performed to evaluate the effects of sugammadex on post-operative pulmonary complications in patients undergoing laparoscopic gastrectomy between 2013 and 2017. We performed propensity score matching to correct for selection bias. Post-operative pulmonary complications (i.e., pneumonia, respiratory failure, pleural effusion, atelectasis, pneumothorax, and aspiration pneumonitis) were evaluated from the radiological and laboratory findings. We also evaluated admission to the intensive care unit after surgery, re-admission or an emergency room visit within 30 days after discharge, length of hospital stay, re-operation, and mortality within 90 days post-operatively as secondary outcomes. In the initial cohort of 3802 patients, 541 patients were excluded, and 1232 patients were analyzed after propensity score matching. In the matched cohort, pleural effusion was significantly reduced in the sugammadex group compared to the neostigmine group (neostigmine 23.4% vs. sugammadex 18%, p = 0.02). Other pulmonary complications and secondary outcomes were not significantly different between the groups. In comparison to neostigmine, the use of sugammadex was associated with a lower incidence of post-operative pleural effusion in laparoscopic gastrectomy.
机译：使用Sugammadex可以减少术后残留的神经肌梗阻，这已知可以增加术后呼吸事件的风险。然而，它对术后肺部并发症的影响并不明显。进行该研究以评估Sugammadex在2013年和2017年之间进行腹腔镜胃切除术后患者的术后肺并发症的影响。我们进行了倾向得分匹配，以纠正选择偏差。从放射学和实验室发现评估了术后肺并发症（即肺炎，呼吸衰竭，胸腔积液，Atelectasis，气胸和吸入肺炎）。我们还在出院后30天内进行手术，重新入场或急诊室访问后的重症监护单位的录取，在术后90天内在次要的90天内在次要后90天内进行急诊室访问。在3802名患者的初始队列中，排除了541名患者，并在倾向得分匹配后分析1232名患者。在匹配的队列中，与Neostigmine组（Neostigmine 23.4％与Sugammadex 18％，P = 0.02）相比，血糖积液在Sugammadex组中显着降低了胸膜积液。这些肺部并发症和二次结果在组之间没有显着差异。与新骨质的相比，使用腹腔镜胃切除术后术后胸腔积液的发病率较低的发生率。

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