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首页> 外文期刊>Journal of Clinical Medicine Research >Determinants of Glycated Hemoglobin in Subjects With Impaired Glucose Tolerance: Subanalysis of the Japan Diabetes Prevention Program
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Determinants of Glycated Hemoglobin in Subjects With Impaired Glucose Tolerance: Subanalysis of the Japan Diabetes Prevention Program

机译：葡萄糖耐量受损的受试者糖化血红蛋白的决定因素：日本糖尿病预防计划的细胞分析

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Background: Limited evidence is available about the relationship of lifestyle factors with glycated hemoglobin (HbA1c) in subjects with impaired glucose tolerance. The aim of study was to identify such determinant factors of HbA1c in subjects with impaired glucose tolerance.Methods: This cross-sectional study included 121 men and 124 women with impaired glucose tolerance, who were diagnosed based on a 75-g oral glucose tolerance test. Demographic and biochemical parameters, including the body mass index (BMI), fasting plasma glucose (FPG), 2-h post-load glucose (2-h PG), and HbA1c, were measured. The pancreatic β-cell function and insulin resistance were assessed using homeostasis model assessment (HOMA-β). Dietary intake was assessed by a food frequency questionnaire.Results: The levels of FPG, 2-h PG, and carbohydrate intake were correlated with the HbA1c level in men, while the FPG and 2-h PG levels were correlated with the HbA1c level in women. In multiple regression analyses, BMI, FPG, 2-h PG, and white rice intake were associated with HbA1c levels in men, while BMI, FPG, HOMA-β, and bread intake were associated with HbA1c levels in women.Conclusions: The present findings suggest that a substantial portion of HbA1c may be composed of not only glycemic but also several lifestyle factors in men with impaired glucose tolerance. These factors can be taken into consideration as modifiable determinants in assessing the HbA1c level for the diagnosis and therapeutic monitoring of the disease course.J Clin Med Res. 2017;9(4):360-365doi: https://doi.org/10.14740/jocmr2928w
机译：背景：有限的证据是关于具有血糖耐受性受损的受试者中具有糖化血红蛋白（HBA1C）的生活方式因子的关系。研究目的是鉴定葡萄酮耐受性受损的受试者HBA1C的这种决定因素。方法：这种横断面研究包括葡萄糖耐量有损的121名男性和124名妇女，他被诊断为基于75克口服葡萄糖耐量检测。测量包括体重指数（BMI），空腹血糖（FPG），2-H后载葡萄糖（2-H PG）和HBA1C的人口统计学和生化参数。使用稳态化模型评估评估胰腺β细胞功能和胰岛素抵抗力（HOMA-β）。通过食物频率调查评估膳食摄入量。结果：FPG，2-H PG和碳水化合物摄入的水平与男性的HBA1C水平相关，而FPG和2-H PG水平与HBA1C水平相关女性。在多元回归分析中，BMI，FPG，2-H PG和白米摄入与男性的HBA1C水平相关，而BMI，FPG，HOMA-β和面包摄入与女性中的HBA1C水平有关。结论：目前结果表明，大部分HBA1C可以不仅由血糖耐受性受损的男性中的血糖，而且是几种生活方式因素组成。这些因素可以考虑到可修饰的决定因素，评估疾病课程诊断和治疗监测的HBA1C水平.J Clin Med Res。 2017; 9（4）：360-365DOI：https：//doi.org/10.14740/jocmr2928w

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