Over the last several years after its initial recognition [1], some attempts have been made to artificially reproduce transient takotsubo syndrome (TTS), a complex and persistently unknown human pathology, by using animal models [2-5]. But, to make experiments be meaningful, can any of these attempts reproduce the essential and distinguishing features of human TTS? This update of the current discussion attempts to clarify what this new entity consists of, what published early experiments meant, and then to suggest new animal models that could better duplicate similar dysfunctional behavior.
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