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首页> 外文期刊>Journal of Clinical Neurology >A Cortical Substrate for Square-Wave Jerks in Progressive Supranuclear Palsy
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A Cortical Substrate for Square-Wave Jerks in Progressive Supranuclear Palsy

机译：用于进行的Supranclecleclecal Palsy中的方波抽搐的皮质衬底

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Background and Purpose Square-wave jerks (SWJs) are the most common saccadic intrusion in progressive supranuclear palsy (PSP), but their genesis is uncertain. We aimed to determine the characteristics of SWJs in PSP (the Richardson subtype) and Parkinson's disease (PD) and to map the brain structures responsible for abnormal SWJ parameters in PSP. Methods Eye movements in 12 patients with PSP, 12 patients with PD, and 12 age-matched healthy controls were recorded using an infrared corneal reflection device. The rate, mean amplitude, and velocity of SWJs were analyzed offline. Voxel-based morphometry using a 3-Tesla MRI scanner was performed to relate changes in brain volume to SWJ parameters. Results The SWJ rate was more than threefold higher in PSP patients than in both PD patients and controls (mean rates: 33.5, 10.3, and 4.3 SWJs per minute, respectively). The volumes of neither the midbrain nor other infratentorial brain regions were correlated with the SWJ rate. Instead, highly significant associations were found for atrophy in the superior, middle, and inferior temporal gyri in the PSP group. Conclusions SWJs in PSP are not mediated by midbrain atrophy. Instead, supratentorial cortical structures located mainly in the temporal lobe appear to be deeply involved in the generation of abnormally high SWJ rates in these patients. Known anatomical connections of the temporal lobe to the superior colliculus and the cerebellum might play a role in SWJ genesis.
机译：背景和目的方波抽搐（SWJS）是进步性激核麻痹（PSP）中最常见的扫视侵入，但它们的成因是不确定的。我们旨在确定PSP（Richardson亚型）和帕金森病（PD）中SWJS的特征，并在PSP中映射负责异常SWJ参数的脑结构。方法使用红外角膜反射装置记录12例PSP患者12名PSP患者和12例患有12名匹配的健康对照。分析了SWJS的速率，平均幅度和速度。进行使用3-Tesla MRI扫描仪的基于体文的形态学，以将脑体积的变化与SWJ参数相关。结果PSP患者的SWJ率比PD患者和对照（平均值：33.5,1.3和4.3个SWJ）在PSP患者中高于PSP患者的三倍以上。中脑和其他InfrateLental大脑区域的体积与SWJ率相关。相反，在PSP组中的上部，中间和较差的颞甘油中发现了高度显着的关联。结论PSP中的SWJS未被中脑萎缩介导。相反，主要位于颞叶的超级皮质结构似乎深入参与了这些患者的异常高SWJ率的产生。颞叶与上针和小脑的已知解剖结构可能在SWJ成因中发挥作用。

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