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Labile Hemoglobin - A Biochemical Entity

机译:不稳定的血红蛋白 - 生物化学实体

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Diabetes mellitus is a major health disease and may vary in clinical presentation and progression. Although Glucose Fasting and Post prandial levels give a measure of the current plasma glucose level, Glycated haemoglobin is the key analyte used to assess the glycemic control and risk of complications of patients with diabetes. Labile hemoglobin A1c is also known as pre-HbA1c or LA1c or pre-glycohemoglobin. It is an unstable form, (a Schiff base) formed during non-enzymatic glycation of hemoglobin. The concentration of labile fraction varies with acute change in plasma glucose level. Labile hemoglobin may potentially interfere in the estimation of HbA1c and cause a falsely low value and may even hamper or delay the prompt treatment required in diabetics. This calls for a detailed and careful study of chromatograms generated for each sample.
机译:糖尿病是一种重大的健康疾病,可能在临床表现和进展中变化。虽然葡萄糖禁食和后折叠水平给出了目前血浆葡萄糖水平的措施,但糖化血红蛋白是用于评估血糖控制和糖尿病患者并发症的关键分析物。不稳定的血红蛋白A1C也称为HBA1C或LA1C或预甘油蛋白。它是在血红蛋白的非酶促糖糖期间形成的不稳定形式(席夫碱)。不稳定级分的浓度随血浆葡萄糖水平的急性变化而变化。不稳定的血红蛋白可能会干扰HBA1C的估计,并导致错误的低值,甚至可能妨碍或延迟糖尿病患者所需的迅速治疗。这次要求对每个样品产生的色谱图进行详细和仔细研究。

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