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首页> 外文期刊>Journal of Clinical Sciences >Prospective study on acute toxicities of external beam radiotherapy in the management of pelvic malignancies in Lagos University Teaching Hospital
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Prospective study on acute toxicities of external beam radiotherapy in the management of pelvic malignancies in Lagos University Teaching Hospital

机译：外梁放射治疗戒指大学教学医院骨盆恶性肿瘤急性毒性的前瞻性研究

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Introduction: Radiation therapy is key to the management of pelvic malignancies. It not only induces cellular death in target organs but also results in adverse effects on the surrounding structures. These side effects are classified as acute or late toxicities based on the timing of its occurrence from the treatment time. The aim of this study was to describe the pattern and management of radiation side effects in pelvic cancer patients treated with external beam radiotherapy (EBR) at Lagos University Teaching Hospital. Methodology: This study was carried out on pelvic cancers patients treated with curative intent over 6 months. The weekly review of treatment related toxicities were graded using the National Cancer Institute Common Toxicity Criteria and analyzed. Results: A total of 106 patients aged between 32 and 83 years were studied. Mean age was 59.2 years and M: F of 3:7. The most common pelvic malignancy seen was cervical cancer in 50.9% of cases; prostate cancer in 17.0%, and endometrial cancer in 15.1%. The most common acute adverse event was perineal skin desquamation in 73.5% patients, genitourinary toxicities in 66% of patients, hematological derangements in 41.5% patients, and gastrointestinal toxicities in 37.7%. Grades 1 and 2 toxicities were the usual complaints in 62.1% patients and severe toxicities (G3 and 4) in 37.9%. Conclusion: Mild-to-moderate acute radiation induced toxicities is a common occurrence following EBR of pelvic cancer. Conservative management of these toxicities makes EBR tolerable and prevents treatment interruption.
机译：介绍：放射治疗是骨盆恶性肿瘤管理的关键。它不仅在靶器官中诱导细胞死亡，而且导致对周围结构的不利影响。这些副作用基于其发生的时间归类为急性或晚期毒性。本研究的目的是描述在拉各斯大学教学医院对外梁放射治疗（EBR）治疗的盆腔癌患者辐射副作用的模式和管理。方法论：本研究进行了在6个月内治疗治疗意图治疗的骨盆癌症患者。使用国家癌症研究所的常见毒性标准进行了对治疗相关毒性的每周审查。结果：研究了106例患者的32至83岁。平均年龄为59.2岁，m：f为3：7。最常见的骨盆恶性肿瘤在50.9％的病例中是宫颈癌;前列腺癌17.0％，子宫内膜癌为15.1％。最常见的急性不良事件是在73.5％患者中脱髓鞘，66％的患者泌尿毒性，41.5％患者血液紊乱，胃肠道毒性37.7％。 1级和2级毒性是62.1％患者和严重毒性（G3和4）的通常投诉，适用于37.9％。结论：轻度至中度急性辐射诱导毒性是盆腔癌EBR后的常见发生。这些毒性的保守管理使EBR可忍受能力并防止治疗中断。

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