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首页> 外文期刊>Journal of Clinical Sciences >Factors associated with mortality in patients with peritonitis presenting for anesthesia and surgery in a tertiary center in Nigeria - A cross-sectional study
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Factors associated with mortality in patients with peritonitis presenting for anesthesia and surgery in a tertiary center in Nigeria - A cross-sectional study

机译：尼日利亚三级中心麻醉和手术患者死亡率相关的因素 - 尼日利亚三级中心 - 横截面研究

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Background: Peritonitis is one of the surgical emergencies commonly encountered by the general surgeons. Sepsis, dehydration, hypovolemia, and multiple organ dysfunctions have been associated with high mortality rate. The study aimed to assess risk factors associated with mortality in patients with peritonitis presenting for anesthesia and surgery in a tertiary institution. Methods: We conducted a prospective cross-sectional study involving consenting patients managed for peritonitis under general anesthesia over a year period. A study proforma was used to collect the data on demographic characteristics and clinical and biochemical parameters. The association between postoperative mortality and demographic characteristics and clinical and biochemical parameters was determined with Chi-square test, and the level of significance was set at P 0.05. Results: A total of 52 adult patients were studied with 38 (73.1%) males and 14 (26.9%) females. The mean age was 39.7 ± 15.3 years. Nineteen patients died, and the mortality rate was 36.5%. Mortality was more in females and in patients more than 50 years (P = 0.917 and P = 0.34), respectively. Preoperative high American Society of Anesthesiologists (ASAs) physical status (P = 0.002), higher Mannheim Peritonitis Index (MPI) scores (P = 0.005), preoperative systolic blood pressure 100 mmHg (P = 0.006) and preoperative respiratory rate more than 30 breaths/min (P = 0.002), serum creatinine level more than 1.5 (P = 0.04), and acidosis (P = 0.02) were statistically significant risk factors for mortality in this study. Conclusion: The mortality following perforation peritonitis is high in our center. Poor outcome is seen in patients with high ASA status, high MPI scores, preoperative shock, acidosis, renal failure, and tachypnea. Proper resuscitation from shock, correction of acidosis, and improving the ASA status will improve survival in patients with perforated peritonitis.
机译：背景：腹膜炎是普通外科医生常常遇到的外科紧急情况之一。脓毒症，脱水，低血脂和多器官功能障碍与高死亡率有关。该研究旨在评估与高等机构内麻醉和手术患者患者死亡率相关的风险因素。方法：我们进行了一项前瞻性横截面研究，涉及在一年内的全身麻醉下对腹膜炎进行腹膜炎进行的同意横断面研究。使用研究形式，用于收集关于人口统计学特征和临床和生化参数的数据。用Chi-Square试验确定术后死亡率和人口统计学特性和临床和生化参数之间的关联，并且在P <0.05时设定了显着性水平。结果：共有52名成年患者进行了38名（73.1％）男性和14例（26.9％）的女性。平均年龄为39.7±15.3岁。 19名患者死亡，死亡率为36.5％。女性和50岁以下的患者的死亡率分别更多（p = 0.917和p = 0.34）。术前高美国麻醉学士学位（ASAS）物理状态（p = 0.002），曼海姆腹膜炎指数（P = 0.005），术前收缩压<100 mmHg（p = 0.006），术前呼吸率超过30呼吸/分钟（p = 0.002），血清肌酐水平超过1.5（p = 0.04），酸中毒（p = 0.02）是本研究中死亡率的统计学显着的危险因素。结论：我们中心穿孔腹膜炎后的死亡率高。在高ASA状态，高MPI评分，术前休克，酸中毒，肾功能衰竭和Tachypnea的患者中，患者会看到差的结果。适当复苏免受休克，纠正酸中毒，改善ASA状态将改善穿孔腹膜炎患者的存活。

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