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首页> 外文期刊>Journal of Clinical Sciences >Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study
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Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study

机译：基础过量和pH作为资源有限设置中次生腹膜炎结果的预测因子 - 前瞻性研究

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Background: Estimation of the serum pH and base excess as determinants of the adequacy of resuscitation may predict the patient outcome in peritonitis. Materials, Patients and Methods: This was a prospective study conducted in University College Hospital, Ibadan, on patients from 18 years and above with diagnosis of secondary peritonitis who had exploratory laparotomy over a 4-month period (January to April 2017). The patients' biodata, pulse rate, blood pressure, and clinical diagnosis were documented. At presentation, the patients were resuscitated with intravenous normal saline and broad-spectrum antibiotics. Each patient had measurements of acid-base status, and pH analyzed at presentation and in the immediate postoperative period (within 1 h) using the I-STAT point of care device. They were followed up for 48 h after the surgery. The changes in base excess and serum pH in survivors and nonsurvivors were described at 48 h after surgery. This was statistically compared using SPSS version 20 (Chicago, IL, USA). Results: A total of 45 patients were recruited comprising 37 males and 8 female patients. The mean age was 40.86 ± 15.45 years. The mean admission base excess was ?4.76 ± 5.41. The mean admission pH was 7.41 ± 0.07. There were 28 (62%) survivors and 17 (38%) mortalities. The pH on admission and base excess values and after surgery demonstrated statistical significance in survivors and nonsurvivors. Conclusion: Changes in base excess and serum pH values are plausible outcome markers in patients with peritonitis resuscitated with early goal-directed therapy.
机译：背景：随着复苏充足性的确定性，血清pH的估计和碱量过剩可以预测腹膜炎的患者结果。材料，患者和方法：这是18岁及以上患者在18岁及以上患者的患者进行了一项前瞻性研究，诊断了在4个月内（2017年1月至4月）的探索性剖腹产术。记录了患者的生物田，脉搏率，血压和临床诊断。在介绍时，用静脉生态盐水和广谱抗生素复苏患者。每位患者的酸碱状态测量，并在呈现和在术后期间（1小时内）分析pH的pH分析。手术后，它们随访48小时。手术后48小时描述了余量和血清pH的碱过量和血清pH的变化。使用SPSS版本20（芝加哥，IL，USA）进行统计比较。结果：招募了45名患者，包括37名男性和8名女性患者。平均年龄为40.86±15.45年。平均入院碱过量是？4.76±5.41。平均入院pH为7.41±0.07。有28个（62％）的幸存者，17名（38％）死亡人数。入院和基础上过量值和手术后的pH值表现出幸存者和非尿道的统计学意义。结论：碱性多余和血清pH值的变化是腹膜炎患者的可粘性结果标志物，随着早期的目标导向治疗。

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