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首页> 外文期刊>Journal of clinical laboratory analysis. >Comparison and evaluation of Abbott chemiluminescent microparticle immunoassay and ChIVD light‐initiated chemiluminescent assay in the detection of Treponema pallidum antibody
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Comparison and evaluation of Abbott chemiluminescent microparticle immunoassay and ChIVD light‐initiated chemiluminescent assay in the detection of Treponema pallidum antibody

机译：雅培化学发光微粒免疫测定和ChiVD光引发化学发光测定在检测Treponema pallidum抗体中的比较与评价

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Background Laboratory tests play an important role in the diagnosis of syphilis. This study aimed to compare and assess the performance of the Abbott chemiluminescent microparticle immunoassay (CMIA) and the ChIVD light‐initiated chemiluminescent assay (LICA) in the detection of Treponema pallidum ( TP ) antibody. Methods A total of 10?498 serum samples were detected with two assays, and the Treponema pallidum particle agglutination assay (TPPA) and recombinant immunoblot assay (RIBA) methods were used for confirmation. The sensitivity, specificity, positive predictive value, and negative predictive value of the Abbott CMIA and ChIVD LICA were calculated. The coincidence rate between two assays was also evaluated. The causes of false positive and false negative of two assays were studied. Results For the Abbott CMIA and ChIVD LICA, the sensitivity was 94.44% and 98.15%, the specificity was 99.89% and 99.81%, the positive predictive value was 93.29% and 88.83%, and the negative predictive value was 99.91% and 99.97%, respectively. The coincidence rate between Abbott CMIA and ChIVD LICA was 99.26%, and κ value was .790. The disease of infertility, hypertensive disease, liver disease, and cancer were the common causes of false positive in both assays, while infertility was also the main reason lead to false negative. Conclusion Our results demonstrated that the Abbott CMIA and ChIVD LICA generally had high sensitivity and specificity and therefore may be suitable for the detection of TP antibody and screening for syphilis.
机译：背景技术实验室试验在梅毒的诊断中发挥着重要作用。本研究旨在比较和评估雅培化学发光微粒免疫测定（CMIA）和Chivd发光的化学发光测定（LICA）在检测Treponema Pallidum（TP）抗体中的性能。方法使用两种测定检测总共10〜498个血清样品，并使用蛋白酶磷酸盐颗粒凝集测定法（TPPA）和重组免疫印迹测定（RIBA）方法进行确认。计算雅培CMIA和Chivd LICA的敏感性，特异性，阳性预测值和负预测值。还评估了两种测定之间的重合率。研究了两种测定的假阳性和假阴性的原因。结果雅培CMIA和Chivd LICA，敏感性为94.44％和98.15％，特异性为99.89％和99.81％，阳性预测值为93.29％和88.83％，负预测值为99.91％和99.97％，分别。雅培CMIA和Chivd LICA之间的巧合率为99.26％，κ值为.790。不孕症，高血压疾病，肝病和癌症的疾病是两种测定中假阳性的常见原因，而不孕症也是导致假阴性的主要原因。结论我们的结果表明，Abbott CMIA和Chivd LICA通常具有高敏感性和特异性，因此可能适用于检测TP抗体和筛选梅毒。

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