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首页> 外文期刊>Journal of International Medical Research >Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features
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Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features

机译：非小细胞肺癌中血压素-1的微血管密度及表达及其与临床病理特征的相关性

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摘要

Microvessel density and thrombospondin-1 (TSP-1) expression were analysed in 42 non-small cell lung cancer (NSCLC) specimens and 40 normal lung tissue specimens using immunohistochemistry. Microvessel density was significantly higher and TSP-1 expression significantly lower in NSCLC tissue compared with normal tissue. Significantly lower levels of TSP-1 expression and higher microvessel densities were found in late-stage NSCLC compared with early-stage NSCLC, and in those with lymph node metastasis compared with those without metastasis. A statistically significant inverse correlation was observed between TSP-1 expression and microvessel density in squamous cell carcinoma but not in adenocarcinoma. These results suggest a close relationship between microvessel density and NSCLC tumour progress, and that a high expression of TSP-1 may play an important role in inhibiting tumour occurrence and development. The lack of correlation between microvessel density and TSP-1 expression in adenocarcinoma suggests that the mechanism of tumour inhibition by TSP-1 varies according to histological type.
机译：在42例非小细胞肺癌（NSCLC）标本和40个正常肺组织标本中，分析了微血管密度和血栓状素-1（TSP-1）表达，使用免疫组化。与正常组织相比，微血管密度明显高，TSP-1表达显着降低了NSCLC组织。与早期NSCLC相比，在后期NSCLC中发现了明显较低的TSP-1表达和更高的微血管密度，与淋巴结转移的那些，与没有转移的那些。在鳞状细胞癌中的TSP-1表达和微血管密度之间观察到统计学上显着的反相，但不在腺癌中。这些结果表明微血管密度和NSCLC肿瘤进展之间的密切关系，TSP-1的高表达可能在抑制肿瘤发生和发育方面发挥重要作用。腺癌中微血管密度和TSP-1表达之间的相关性表明TSP-1肿瘤抑制的机制根据组织学类型而变化。

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